The 1949–50 Serie C was the twelfth edition of Serie C, the third highest league in the Italian football league system.
To reduce the groups into an 18-team formula, additional relegations were added during the season. However, the plan was later partially postponed.
Legend
  Promoted
  Relegated
| Girone A
 Source:  Notes: | Girone B
 Source:  Notes: 
 
 | 
| Girone C
 Source:  Notes: | Girone D
 Source:  Notes: 
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