4-Cyano-3-(trifluoromethyl)aniline

4-Cyano-3-(trifluoromethyl)aniline
Names
	Preferred IUPAC name 4-Amino-2-(trifluoromethyl)benzonitrile
	Other names 4-Cyano-3-(trifluoromethyl)aniline
Identifiers
CAS Number	654-70-6;
3D model (JSmol)	Interactive image;
ChemSpider	455494;
ECHA InfoCard	100.109.189
PubChem CID	522170;
UNII	L47D9XHC08;
CompTox Dashboard (EPA)	DTXSID80215711 ;
	SMILES C1=CC(=C(C=C1N)C(F)(F)F)C#N;
Properties
Chemical formula	C8H5F3N2
Molar mass	186.137 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

4-Cyano-3-(trifluoromethyl)aniline, also known as 4-amino-2-(trifluoromethyl)benzonitrile, is a cyanated and trifluoromethylated derivative of aniline. It is the starting material in one of the chemical syntheses of the nonsteroidal antiandrogen bicalutamide.^[1]

References

↑ Tucker H, Crook JW, Chesterson GJ (1988). "Nonsteroidal antiandrogens. Synthesis and structure-activity relationships of 3-substituted derivatives of 2-hydroxypropionanilides". Journal of Medicinal Chemistry. 31 (5): 954–9. doi:10.1021/jm00400a011. PMID 3361581.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.