Charles Spencer-Churchill may refer to:
- Lord Charles Spencer-Churchill (1794–1840), British nobleman
 - Charles Henry Spencer-Churchill (1828–1877), British officer
 - Charles Spencer-Churchill, 9th Duke of Marlborough (1871–1934)
 - James Spencer-Churchill, 12th Duke of Marlborough (born 1955), full name Charles James Spencer-Churchill
 
See also
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