Defries or De Fries is a surname. Notable people with the surname include:
People
- Colin Defries (1884–1963), English racing driver and pilot
- Graham Francis Defries, partner in the law firm Goodwin Procter
- Joel Defries (born 1985), British-born presenter
- Robert Defries (1889–1975), Canadian physician
- Tony Defries (born 1943), British music manager and impresario
- Phil De Fries (born 1987), British mixed martial artist
- Heinrich de Fries (1887–1938), German architect
See also
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