Kühne is a surname. Notable people with the surname include:
Business
- August Kühne (1855–1932), German businessman, co-founder of Kuehne + Nagel
 - Alfred Kühne (1895–1981), son of August, German businessman
 - Klaus-Michael Kühne (born 1937), son of Alfred, German businessman, honorary chairman of Kühne + Nagel
 
Sports
- Anke Kühne (born 1981), German field hockey player
 - Frank Kühne (born 1961), German swimmer
 - Marc Kühne (born 1976), German bobsledder
 - Matthias Kühne (born 1987), German footballer
 - Rico Kühne (born 1982), German footballer
 - Rita Kühne (born 1947), former East German athlete
 - Simon Kühne (born 1994), Liechtensteiner footballer
 - Stefan Kühne (born 1980), German footballer
 
Other people
- Alfred von Kühne (1853-1945), German general during World War I
 - Eric Kuhne (1951–2016), American-born British architect
 - Friedrich Kühne (1870–1959), German film actor of the silent era
 - Hans Kühne (1880–1969), German chemist
 - Helmut Kuhne (born 1949), German politician
 - Louis Kuhne (1835–1901), German naturopath
 - Otto Kühne (1893–1955), German antifascist militant
 - Rainer Walter Kühne (born 1970), German theoretical physicist
 - Roy Kühne (born 1967), German politician
 - Thomas Kühne (born 1958), German historian
 - Walter Georg Kühne (1911–1991), German paleontologist
 - Wilhelm Kühne (disambiguation), several people
 
See also
- Koehne, or Köhne, a related surname
 - Altmann & Kühne, a confiserie and chocolaterie in Vienna, Austria
 - Carl Kühne KG, a German food company
 - Kühne Logistics University, in Schindellegi, Switzerland
 - Karls kühne Gassenschau, a Swiss circus
 
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