Koff may refer to:
- Koff (beer), a Finnish beer brewed by Sinebrychoff
- Koff (coffee substitute), a coffee substitute
- Clea Koff (British-born American forensic anthropologist) (born 1972)
- Offutt Air Force Base (ICAO code KOFF)
- Koff (ship type), a historical type of sailing vessel in the North Sea
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