McCombie is a surname. Notable people with the surname include:
- Andy McCombie (1876–1952), Scottish international footballer
 - Karen McCombie (born 1963), author of children and young adult novels
 - William McCombie (1805–1880), Scottish agriculturist famed for a herd of black-polled cattle
 
See also
- Barton–McCombie deoxygenation, organic reaction replacing a hydroxy group with hydrogen to give an alkyl group
 
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