Pompholyx may refer to:

  • Pompholyx, certain eczema, see dyshidrosis
  • Pompholyx (rotifer), a genus of rotifers in the family Testudinellidae
  • Pompholyx, a genus of insects in the family Pneumoridae, synonym of Prostalia
  • Pompholyx, a genus of fungi in the family Sclerodermataceae, synonym of Scleroderma
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