R134, R 134, or R-134 may refer to:
- R-134 (hydrofluorocarbon), also called 1,1,2,2-tetrafluoroethane, a chemical.
- R134 (star), a Wolf-Rayet star in the Tarantula Nebula.
- R134, an R boat, a German naval vessel built during the Second World War.
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