Van Dyne is a Dutch surname.
Notable people with the name include:
- George Van Dyne (1933–1981), pioneer of systems ecology
 - Janet van Dyne, a fictional superhero appearing in Marvel Comics
 - Van Dyne, Wisconsin, unincorporated census-designated place in Fond du Lac County, Wisconsin
 - Van Dyne Civic Building, historic courthouse building located in Bradford County, Pennsylvania
 - Van Dyne Crotty, American uniform laundering and rental company
 - Vernon Van Dyne, distinguished U.S. Army Officer
 
See also
- Dyne, a unit of force
 
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