Ōsaki, Osaki, Oosaki or Ohsaki (written: 大崎, 大﨑, or 桜咲) is a Japanese surname. Notable people with the surname include:
- Junya Osaki (大﨑 淳矢, born 1991), Japanese footballer
- Leo Osaki (大崎 玲央, born 1991), Japanese-born American soccer player
- Makoto Osaki, developer and supervisor at Sega AM2, involved with the Shenmue, Out Run, and Virtua Fighter games, among others
- Sakae Osaki (大崎 栄, born 1964), Japanese long-distance runner
- Yoshihiko Osaki (大崎 剛彦, born 1939–2015), Japanese swimmer
- Yutaro Ohsaki (大﨑 雄太朗, born 1984), Japanese baseball player
Fictional characters
- Nana Osaki (大崎 ナナ), a character in the manga series Nana
- Akane Osaki (桜咲 朱音), a character in the manga series Akane-banashi
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