The quarterfinals were two-legged ties determined on aggregate score. The first legs were played on March 20. The return legs were played on March 27. The group winners in each tie, listed as "Team #1", hosted the second leg.

Team #1 Agg. Team #2 1st leg 2nd leg
Valencia Basket Spain156–138Montenegro Budućnost Voli71–7585–63
Donetsk Ukraine145–154Lithuania Lietuvos Rytas65–7680–78
Spartak St. Petersburg Russia154–135Czech Republic ČEZ Nymburk68–6486–71
Lokomotiv-Kuban Russia153–158Russia Khimki72–8181–77

All times are CET (UTC+1).

Game 1

19 March 2012
19:00
ČEZ Nymburk Czech Republic 6468 Russia Spartak St. Petersburg
Scoring by quarter: 21–17, 18–26, 9–16, 16–9
Pts: Simmons 23
Rebs: Wilson 6
Asts: Lawrence, Simmons 3
Pts: Beverley 19
Rebs: Keyru 6
Asts: Strēlnieks 4
ČEZ Aréna, Pardubice
Attendance: 3,165
Referees: Miguel Perez (ESP), Juan Carlos Garcia Gonzalez (ESP), Marcin Kowalski (POL)

20 March 2012
16:00
Khimki Russia 8172 Russia Lokomotiv-Kuban
Scoring by quarter: 18–21, 22–21, 19–18, 22–12
Pts: Kelati 20
Rebs: Monia 7
Asts: Quinn 5
Pts: Massey, Rivers 14
Rebs: Traore 8
Asts: Ilievski 5
Basketball Center of Moscow Region, Khimki
Attendance: 2,850
Referees: Christos Christodoulou (GRE), Sinisa Herceg (CRO), Petri Mantyla (FIN)

20 March 2012
18:00
Lietuvos Rytas Lithuania 7665 Ukraine Donetsk
Scoring by quarter: 18–9, 23–22, 20–18, 15–16
Pts: Babrauskas 15
Rebs: Valančiūnas 10
Asts: Rice 7
Pts: Radenović 16
Rebs: Radenović 10
Asts: Avdalović 4
Siemens Arena, Vilnius
Attendance: 9,200
Referees: Recep Ankarali (TUR), Milivoje Jovcic (SRB), Damir Javor (SLO)

20 March 2012
18:30
Budućnost Voli Montenegro 7571 Spain Valencia Basket
Scoring by quarter: 20–21, 20–18, 14–22, 21–10
Pts: Dubljević 15
Rebs: Dubljević 8
Asts: A. Popović, Anderson 3
Pts: de Colo 12
Rebs: Claver 7
Asts: Marković 7
Morača Sports Center, Podgorica
Attendance: 3,100
Referees: Guerrino Cerebuch (ITA), Elias Koromilas (GRE), Tomas Trawicki (POL)

Game 2

27 March 2012
17:00
Spartak St. Petersburg Russia 8671 Czech Republic ČEZ Nymburk
Scoring by quarter: 21–18, 23–21, 26–17, 16–15
Pts: Strēlnieks, Halperin 19
Rebs: Beverley 7
Asts: Halperin 7
Pts: Simmons 22
Rebs: Pumprla, Simmons 7
Asts: Lawrence 7
Yubileyny Sports Palace, Saint Petersburg
Attendance: 2,700
Referees: Sreten Radovic (CRO), Roberto Chiari (ITA), Radomir Vojinovic (MNE)

27 March 2012
17:00
Lokomotiv-Kuban Russia 8177 Russia Khimki
Scoring by quarter: 22–24, 11–22, 26–16, 22–15
Pts: Traore 22
Rebs: Massey 8
Asts: Rivers 2
Pts: Fridzon 17
Rebs: Fridzon 7
Asts: Quinn 5
Olympus Arena, Krasnodar
Attendance: 4,000
Referees: Daniel Hierrezuelo (ESP), Spiros Gkontas (GRE), Rustu Nuran (TUR)

27 March 2012
18:00
Donetsk Ukraine 8078 Lithuania Lietuvos Rytas
Scoring by quarter: 17–28, 17–13, 13–13, 33–24
Pts: Curry 26
Rebs: Radenović 8
Asts: Avdalović, Radenović 4
Pts: Rice 14
Rebs: Valančiūnas 7
Asts: Rice 5
Druzhba Palace of Sports, Donetsk
Attendance: 4,000
Referees: Vicente Bulto (ESP), Antonio Conde (ESP), Zdravko Rutesic (MNE)

27 March 2012
20:30
Valencia Basket Spain 8563 Montenegro Budućnost Voli
Scoring by quarter: 28–11, 16–17, 28–14, 13–21
Pts: Claver 13
Rebs: Caner-Medley 8
Asts: de Colo 5
Pts: Dubljević 17
Rebs: Vitkovac 6
Asts: Anderson 5
Pabellon Municipal Fuente San Luis, Valencia
Attendance: 8,800
Referees: Luis Lopes (POR), Boris Shulga (UKR), Panagiotis Anastopoulos (GRE)
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