3,5-Difluoro-4-hydroxybenzylidene imidazolinone

3,5-Difluoro-4-hydroxybenzylidene imidazolinone
Names
	IUPAC name (5Z)-5-[(3,5-Difluoro-4-hydroxyphenyl)methylene]-3,5-dihydro-2,3-dimethyl-4H-imidazol-4-one
	Other names DFHBI; 3,5-Difluoro-4-hydroxybenzylidene imidazolidinone; (Z)-4-(3,5-Difluoro-4-hydroxybenzylidene)-1,2-dimethyl-1H-imidazol-5(4H)-one;
Identifiers
CAS Number	1241390-29-3;
3D model (JSmol)	Interactive image;
ChemSpider	35035087;
PubChem CID	70808995;
	InChI InChI=1S/C12H10F2N2O2/c1-6-15-10(12(18)16(6)2)5-7-3-8(13)11(17)9(14)4-7/h3-5,17H,1-2H3/b10-5- Key: ZDDIJYXDUBFLID-YHYXMXQVSA-N;
	SMILES CC1=N/C(=C\C2=CC(=C(C(=C2)F)O)F)/C(=O)N1C;
Properties
Chemical formula	C12H10F2N2O2
Molar mass	252.221 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

3,5-Difluoro-4-hydroxybenzylidene imidazolinone or DFHBI^[1] is an imidazolinone fluorophore used in various biochemical studies. The benzene ring of DFHBI can freely rotate around the single bond but when it is fixed in planar conformation, DFHBI fluoresces.^[2] It is a synthetic analog of the GFP fluorophore.

References

1 2 "DFHBI 1241390-29-3". Sigma Aldrich. Archived from the original on 2022-01-13.
1 2 Dou, Jiayi; Vorobieva, Anastassia A.; Sheffler, William; Doyle, Lindsey A.; Park, Hahnbeom; Bick, Matthew J.; Mao, Binchen; Foight, Glenna W.; Lee, Min Yen; Gagnon, Lauren A.; Carter, Lauren (September 2018). "De novo design of a fluorescence-activating β-barrel". Nature. 561 (7724): 485–491. Bibcode:2018Natur.561..485D. doi:10.1038/s41586-018-0509-0. ISSN 0028-0836. PMC 6275156. PMID 30209393.

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[Sigma-1] 1 2 "DFHBI 1241390-29-3". Sigma Aldrich. Archived from the original on 2022-01-13.

[barrel-2] 1 2 Dou, Jiayi; Vorobieva, Anastassia A.; Sheffler, William; Doyle, Lindsey A.; Park, Hahnbeom; Bick, Matthew J.; Mao, Binchen; Foight, Glenna W.; Lee, Min Yen; Gagnon, Lauren A.; Carter, Lauren (September 2018). "De novo design of a fluorescence-activating β-barrel". Nature. 561 (7724): 485–491. Bibcode:2018Natur.561..485D. doi:10.1038/s41586-018-0509-0. ISSN 0028-0836. PMC 6275156. PMID 30209393.

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