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IUPAC name
5,6-Dichloro-1-(β-D-ribofuranosyl)-1H-1,3-benzimidazole | |
Systematic IUPAC name
(2R,3R,4S,5R)-2-(5,6-Dichloro-1H-1,3-benzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol | |
Other names
DRB, Dichlororibofuranosylbenzimidazole | |
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Properties | |
C12H12Cl2N2O4 | |
Molar mass | 319.14 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references |
5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) is a chemical compound that inhibits transcription elongation by RNA Polymerase II. Sensitivity to DRB is dependent on DRB sensitivity inducing factor (DSIF), negative elongation factor (NELF), and positive transcription elongation factor b (P-TEFb). DRB is a nucleoside analog and also inhibits some protein kinases.[1]
References
- ↑ Yamaguchi, Y.; Takagi, T.; Wada, T.; Yano, K.; Furuya, A.; Sugimoto, S.; Hasegawa, J.; Handa, H. (1999). "NELF, a Multisubunit Complex Containing RD, Cooperates with DSIF to Repress RNA Polymerase II Elongation". Cell. 97 (1): 41–51. doi:10.1016/S0092-8674(00)80713-8. PMID 10199401.
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