Decaprenyl-phosphate phosphoribosyltransferase
Identifiers
EC no.2.4.2.45
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IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
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Decaprenyl-phosphate phosphoribosyltransferase (EC 2.4.2.45, 5-phospho-alpha-D-ribose-1-diphosphate:decaprenyl-phosphate 5-phosphoribosyltransferase, 5-phospho-alpha-D-ribose 1-pyrophosphate:decaprenyl phosphate 5-phosphoribosyltransferase, DPPR synthase, Rv3806) is an enzyme with systematic name trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate:diphosphate phospho-alpha-D-ribosyltransferase.[1] This enzyme catalyses the following chemical reaction

trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate

This enzyme requires Mg2+. It is isolated from Mycobacterium tuberculosis.

References

  1. Huang H, Scherman MS, D'Haeze W, Vereecke D, Holsters M, Crick DC, McNeil MR (July 2005). "Identification and active expression of the Mycobacterium tuberculosis gene encoding 5-phospho-{alpha}-d-ribose-1-diphosphate: decaprenyl-phosphate 5-phosphoribosyltransferase, the first enzyme committed to decaprenylphosphoryl-d-arabinose synthesis". The Journal of Biological Chemistry. 280 (26): 24539–43. doi:10.1074/jbc.m504068200. PMID 15878857.
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