Barry Ween

Barry is ten years old and by far the smartest organism on the planet. No explanation is ever provided for his vast intellect, although the first issue begins with Barry stating that "I was smart even before birth, and I'm not talking a little smart. I mean way smart, like, self-awareness-in-the-womb-smart." He is an extremely prolific inventor and has built an immense secret lair underneath his suburban home full of robots, futuristic transports, and weapons. Due to his knowledge of the workings of the human body, he is exceptionally skilled at hand-to-hand combat. Despite his genius, however, Barry is prone to making errors in his experiments that can lead to near-catastrophic consequences, like turning his aunt into an enormous deformed blob, knocking the Earth out of the Sun's orbit, or accidentally creating an inter-dimensional rift in his basement. He copes with his unusual lifestyle by adopting a sardonic sense of humor and a thinly veiled contempt for most of his schoolmates. Despite the great power that his intelligence grants him, he admits later in the series that his superior mind is a kind of curse: he cannot stop thinking, calculating probabilities, and formulating plans; so he never sleeps. In fact, he attends school because he believes social interaction will slow his descent into madness.

Jeremy Ramirez

Jeremy is the only human to know of Barry's abilities (other characters have discovered them at various points in the series, only to have Barry erase their memories). Like Barry, Jeremy is a profane and irreverent ten-year-old, although Jeremy shows a great deal less maturity and restraint. He has an enormous and somewhat curious interest in women, despite not having yet entered puberty. He tags along for all of Barry's adventures, usually to provide comic relief. He fervently denies any attraction to Roxie (despite evidence to the contrary). When asked by Roxie why he keeps Jeremy around, Barry replies that he enjoys having someone not in awe of his genius or asking questions to keep him a bit grounded.

Sara Tan

A classmate and friend to Barry and Jeremy, Sara (sometimes spelled "Sarah," most likely a typo) is probably the smartest character in the series next to Barry. She is confident, brave, and resourceful; qualities that have made her an able participant in some of Barry's more dangerous escapades. Barry is very attracted to her, and dealing with their relationship has been perhaps one of the few challenges he cannot surmount with his intelligence alone. It is not clear to what degree Sara reciprocates this affection, although she clearly likes and respects Barry. She has twice learned of his intelligence, but Barry erased her memory the first time and altered the past through time travel the second time in order to save her from death. Though Sara's death was averted, Barry was intensely - though privately - devastated by the experience.

Whether or not Barry will eventually admit her into his confidence remains to be seen.

Roxie

Roxie is a Bigfoot whom Barry and Jeremy met when Barry's parents were kidnapped and nearly eaten by another Sasquatch. Far more intelligent and ambitious than the lazy majority of her kind, she was able to secure Barry's help in removing most of her hair so that she could pass for human. Despite looking like an eleven-year-old girl, Roxie is extremely strong, fast and agile, and often forgets that she must pretend to be weaker to maintain her cover. She is a voracious reader, and prior to meeting Barry used to break into libraries in order to gain access to books. She has so far only appeared in two issues.

From Barry

• "Color me nine different shades of not giving a fuck!"
• "Considering [Jeremy's] attention span now, imagine him at five. He was like a hummingbird on crack."
• "In The Sun Also Rises, Ernest Hemingway describes genius as the ability to learn at a greater velocity. For a suicidal drunk with a pathological fear of latent homosexuality, Papa did all right."
• "When asked if he felt like a failure after his 'ten thousandth' unsuccessful attempt to create a working electric light bulb, Thomas Alva Edison said: 'Why? I have not failed. I've just found ten thousand ways that won't work.' What an asshole. Smart guy, but also a patent thief that had an ego to almost eclipse the mountain of self-importance I possess."
• "At 8 months of age, I made my first high-powered telescope by cannibalizing a video camera and an Atari 2600 (not like anyone was going to miss it). And my studies have concluded that extraterrestrials exist...and they're generally a bunch of jerk-offs. Alien visitation to Earth falls into two categories. One: The National Geographic Special. These are camera crews who come to Earth to film us in our natural habitat. And Two: The intergalactic equivalent of cow-tipping. It's predominately drunken alien frat-boys mutilating cattle, flying in observed airspace, and anal probing. But there are exceptions to these two categories..."

From Roxie

• "These douchebags wouldn't know a book if one crawled up their furry gams and started blowing them!" (Referring to the other Sasquatches' lack of learning and intelligence)
• "Ray-Ray couldn't find his asshole with a stick and eight hands." (They apparently also have a lousy sense of direction)

Collected editions

The series has been collected into a number of trade paperbacks:

• The Adventures of Barry Ween: Boy Genius, Volume 1 (collects vol. 1 #1-3, August 2000, Oni Press, ISBN 1-929998-00-7)
• The Adventures of Barry Ween: Boy Genius, Volume 2 - 2.0 (collects vol. 2 #1-3, 2001, Oni Press, ISBN 978-0-9299-9805-3)
• The Adventures of Barry Ween: Boy Genius, Volume 3 - Monkey Tales (collects Monkey Tales #1-3, 2001, Oni Press, ISBN 1-929998-18-X)
• The Adventures of Barry Ween: Boy Genius, Volume 4 - Gorilla Warfare (collects Monkey Tales #4-6, 2002, Oni Press, ISBN 978-1-9299-9819-7)
• The Big Book of Barry Ween: Boy Genius (collects all 12 issues of all 3 limited series, 2008, Oni Press, ISBN 978-1-9349-6402-6)

Other appearances

• Oni Press Color Special 2001 (one-shot, June 2001, Oni Press)
  • Barry makes an appearance in the opening story, Who Killed Madman?, as rendered by Mike Allred