Axon is an English surname. Notable people with this surname include the following:
- Annemarie Carney Axon, American judge
- David Axon (1951–2012), British astrophysicist
- John Axon (1900–1957), English engine driver awarded the George Cross
- John Axon (actor) (1960–2008), English actor; grandson of John Axon the engine driver
- Rachael Axon (b. 1985), English footballer
- William Axon (1846–1913), English antiquary
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