DTX3L

DTX3L
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3PG6
Identifiers
Aliases	DTX3L, BBAP, deltex 3 like, E3 ubiquitin ligase, deltex E3 ubiquitin ligase 3L, RNF143
External IDs	OMIM: 613143 MGI: 2656973 HomoloGene: 51375 GeneCards: DTX3L
Gene location (Human)
Chr.	Chromosome 3 (human)
End	122,575,203 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	35,759,521 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; lower lobe of lung; ; pericardium; ; germinal epithelium; ; pylorus; ; human penis; ; palpebral conjunctiva; ; jejunal mucosa; ; synovial membrane; ; superficial temporal artery;
	Top expressed in
	jejunum; ; seminal vesicula; ; submandibular gland; ; blood; ; ileum; ; cervix; ; subcutaneous adipose tissue; ; thymus; ; left colon; ; spleen;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; metal ion binding; ubiquitin-protein transferase activity; transferase activity; enzyme inhibitor activity; enzyme activator activity; enzyme binding; histone binding; ubiquitin-like protein ligase binding; STAT family protein binding;
Cellular component	cytoplasm; nucleus; nucleoplasm; cytosol; early endosome; lysosome; lysosomal membrane; endosome; membrane; early endosome membrane; protein-containing complex;
Biological process	histone monoubiquitination; double-strand break repair; DNA repair; protein ubiquitination; cellular response to DNA damage stimulus; protein polyubiquitination; positive regulation of defense response to virus by host; endosome to lysosome transport; positive regulation of protein binding; histone H2A ubiquitination; histone H2B ubiquitination; positive regulation of chromatin binding; positive regulation of transcription, DNA-templated; negative regulation of ubiquitin-protein transferase activity; protein autoubiquitination; protein K48-linked ubiquitination; positive regulation of protein localization to nucleus; positive regulation of NAD+ ADP-ribosyltransferase activity; positive regulation of protein localization to early endosome; positive regulation of receptor catabolic process; positive regulation of double-strand break repair via nonhomologous end joining; immune system process; protein transport; innate immune response; defense response to virus; chromatin organization; ubiquitin-dependent protein catabolic process; Notch signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	151636
	209200
	ENSG00000163840
	ENSMUSG00000049502
	Q8TDB6
	Q3UIR3
	NM_138287
	NM_001013371
	NP_612144
	NP_001013389
	Wikidata
View/Edit Human	View/Edit Mouse

Deltex E3 ubiquitin ligase 3L is a protein that in humans is encoded by the DTX3L gene. ^[5]

Function

DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163840 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049502 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Deltex E3 ubiquitin ligase 3L". Retrieved 2017-03-26.

Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA (2003). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". J. Biol. Chem. 278 (24): 21930–7. doi:10.1074/jbc.M301157200. PMID 12670957.
Juszczynski P, Kutok JL, Li C, Mitra J, Aguiar RC, Shipp MA (2006). "BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate". Mol. Cell. Biol. 26 (14): 5348–59. doi:10.1128/MCB.02351-05. PMC 1592708. PMID 16809771.
Wilting SM, de Wilde J, Meijer CJ, Berkhof J, Yi Y, van Wieringen WN, Braakhuis BJ, Meijer GA, Ylstra B, Snijders PJ, Steenbergen RD (2008). "Integrated genomic and transcriptional profiling identifies chromosomal loci with altered gene expression in cervical cancer". Genes Chromosomes Cancer. 47 (10): 890–905. doi:10.1002/gcc.20590. PMC 2733213. PMID 18618715.
Yan Q, Dutt S, Xu R, Graves K, Juszczynski P, Manis JP, Shipp MA (2009). "BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response". Mol. Cell. 36 (1): 110–20. doi:10.1016/j.molcel.2009.08.019. PMC 2913878. PMID 19818714.
Obiero J, Walker JR, Dhe-Paganon S (2012). "Fold of the conserved DTC domain in Deltex proteins". Proteins. 80 (5): 1495–9. doi:10.1002/prot.24054. PMID 22411408. S2CID 40043949.
Yan Q, Xu R, Zhu L, Cheng X, Wang Z, Manis J, Shipp MA (2013). "BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8". Mol. Cell. Biol. 33 (4): 845–57. doi:10.1128/MCB.00990-12. PMC 3571337. PMID 23230272.
Holleman J, Marchese A (2014). "The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4". Mol. Biol. Cell. 25 (12): 1892–904. doi:10.1091/mbc.E13-10-0612. PMC 4055268. PMID 24790097.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163840 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049502 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Deltex E3 ubiquitin ligase 3L". Retrieved 2017-03-26.

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Function

References

Further reading