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Big Shot may refer to:

Fiction

• Big Shot, an animated superhero character on the television show The Tick created by cartoonist Ben Edlund in 1986
• Big Shot, the former mascot of the Philadelphia 76ers until 1996
• Big Shot, a fictional TV show in the 1998 anime Cowboy Bebop
• Big Shot (TV series), an American television series developed by Dean Lorey and David E. Kelley
• Big Shot, an antagonist in the Marvel UK comic Death's Head
• The Big Shot (1922 film), a German silent film
• The Big Shot (1931 film), a pre-Code comedy directed by Ralph Murphy, starring Eddie Quillan and Maureen O'Sullivan
• The Big Shot (1937 film), a comedy directed by Edward Killy, starring Guy Kibbee and Cora Witherspoon
• The Big Shot (1942 film), an American film noir crime drama directed by Lewis Seiler, starring Humphrey Bogart and Irene Manning
• Big Shot Comics, a 1940s comic book series, an anthology title published by Columbia Comics
• Big Shot: Confessions of a Campus Bookie, a 2002 television film starring David Krumholtz
• Big Shots (film), a 1987 American comedy adventure film directed by Robert Mandel, starring Ricky Busker and Darius McCrary
• Big Shots (TV series), a 2007–2008 American television drama series
• "Big Shots" (CSI: Crime Scene Investigation), an episode of CSI: Crime Scene Investigation
• Diary of a Wimpy Kid: Big Shot, a 2021 children's novel by Jeff Kinney

Music

• "Big Shot", a song by the Bonzo Dog Doo-Dah Band from their 1967 album Gorilla
• "Big Shot" (song), a song by Billy Joel, from his 1978 album 52nd Street
• "Big Shot", a song by The Beat (The English Beat) from their 1980 album I Just Can't Stop It
• "Big Shot", a 2003 song by Kill Hannah
• Big Shots (album), a 2003 album by Charizma & Peanut Butter Wolf
• Big Shots Bonus EP, the 2004 follow-up by Charizma & Peanut Butter Wolf
• "Big Shot", a song by Drake Bell from his 2011 EP A Reminder
• "Big Shot", a song by Islander, the theme song of the Bound for Glory wrestling event
• "Big Shot", a song by Kendrick Lamar and Travis Scott from the Black Panther soundtrack
• "Big Shot", a song by the Lumineers for their album Brightside
• "BIG SHOT", a 2021 track by Toby Fox from Deltarune, Chapter 2

Photography

• Big Shot, a Polaroid instant camera manufactured from 1971 to 1973
• Bigshot (digital camera), a 2013 build-it-yourself digital camera designed for ages 8 to 14

Other

• Big Shot (ride), an amusement ride, opened 1996, on top of the Stratosphere Las Vegas tower
• Big Shot (pinball), a pinball machine created in 1973 by Gottlieb
• Big Shot, a New Orleans-based soda brand by National Beverage subsidiary Winnsboro Beverage Packers
• Big Shot, a 2013 episode of ESPN 30 for 30 documentary about the purchase and ownership of the National Hockey League's New York Islanders by John Spano
• Mr. Big Shot, nickname for American basketball player Chauncey Billups
• Frank Fisher (rugby league) (1905–1980), Australian player nicknamed "Big Shot"