Blome is a surname of:
- Fanny Blomé (born 1990) is a Swedish model
- Gert Blomé (born 1934), Swedish ice hockey player
- Heinz-Jürgen Blome (1946–2012) German football player
- Kurt Blome (1894–1969), German scientist
- Nikolaus Blome (born 1963), German journalist
- Richard Blome (1635–1705), British publisher and cartographer
- Blome (composer), 15th-century English composer
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