Bluetongue virus
Electron micrograph of "Bluetongue virus", scale bar = 50 nm
Electron micrograph of Bluetongue virus, cale bar = 50 nm
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Duplornaviricota
Class: Resentoviricetes
Order: Reovirales
Family: Sedoreoviridae
Genus: Orbivirus
Species:
Bluetongue virus

Bluetongue disease is a noncontagious, insect-borne, viral disease of ruminants, mainly sheep and less frequently cattle,[1] yaks,[2] goats, buffalo, deer, dromedaries, and antelope. It is caused by Bluetongue virus (BTV). The virus is transmitted by the midges Culicoides imicola, Culicoides variipennis, and other culicoids.

Signs

Infected sheep
A domestic yak is infected with Bluetongue virus. The tongue is swollen, cyanotic, and protruding from the mouth.

In sheep, BTV causes an acute disease with high morbidity and mortality. BTV also infects goats, cattle, and other domestic animals, as well as wild ruminants (for example, blesbuck, white-tailed deer, elk, and pronghorn antelope).[3]

Major signs are high fever, excessive salivation, swelling of the face and tongue, and cyanosis of the tongue. Swelling of the lips and tongue gives the tongue its typical blue appearance, though this sign is confined to a minority of the animals. Nasal signs may be prominent, with nasal discharge and stertorous respiration.

Some animals also develop foot lesions, beginning with coronitis, with consequent lameness. In sheep, this can lead to knee-walking. In cattle, constant changing of position of the feet gives bluetongue the nickname the dancing disease.[4] Torsion of the neck (opisthotonos or torticollis) is observed in severely affected animals.

Not all animals develop signs, but all those that do lose condition rapidly, and the sickest die within a week. For affected animals that do not die, recovery is very slow, lasting several months.

The incubation period is 5–20 days, and all signs usually develop within a month. The mortality rate is normally low, but it is high in susceptible breeds of sheep. In Africa, local breeds of sheep may have no mortality, but in imported breeds, it may be up to 90%.[5]

In cattle, goats, and wild ruminants, infection is usually asymptomatic despite high virus levels in blood. Red deer are an exception, and in them the disease may be as acute as in sheep.[6]

Microbiology

Bluetongue is caused by the pathogenic virus, Bluetongue virus (BTV),[3] of the genus Orbivirus, of the Reoviridae family. Twenty-seven serotypes are now recognised for this virus.[7] The twenty-seven serotypes are the result of the high variability of a single outer capsid protein, VP2.

The virus particle consists of 10 strands of double-stranded RNA surrounded by two protein shells. Unlike other arboviruses, BTV lacks a lipid envelope. The particle has a diameter of 86 nm.[8] The structure of the 70 nm core was determined in 1998 and was at the time the largest atomic structure to be solved.[9]

The two outer capsid proteins, VP2 and VP5, mediate attachment and penetration of BTV into the target cell. VP2 and VP5 are the primary antigenic targets for antibody targeting by the host immune system. The virus makes initial contact with the cell with VP2, triggering receptor-mediated endocytosis of the virus. The low pH within the endosome then triggers BTV's membrane penetration protein VP5 to undergo a conformational change that disrupts the endosomal membrane.[8] Uncoating yields a transcriptionally active 470S core particle which is composed of two major proteins VP7 and VP3, and the three minor proteins VP1, VP4 and VP6 in addition to the dsRNA genome. There is no evidence that any trace of the outer capsid remains associated with these cores, as has been described for reovirus. The cores may be further uncoated to form 390S subcore particles that lack VP7, also in contrast to reovirus. Subviral particles are probably akin to cores derived in vitro from virions by physical or proteolytic treatments that remove the outer capsid and causes activation of the BTV transcriptase. In addition to the seven structural proteins, three non-structural (NS) proteins, NS1, NS2, NS3 (and a related NS3A) are synthesised in BTV-infected cells. Of these, NS3/NS3A is involved in the egress of the progeny virus. The two remaining non-structural proteins, NS1 and NS2, are produced at high levels in the cytoplasm and are believed to be involved in virus replication, assembly and morphogenesis.[3]

Evolution

The viral genome is replicated via structural protein VP1, an RNA-dependent RNA polymerase.[7] The lack of proof-reading abilities results in high levels of transcription errors, resulting in single nucleotide mutations. Despite this, the BTV genome is quite stable, exhibiting a low rate of variants arising in populations.[10] Evidence suggests this is due to purifying selection across the genome as the virus is transmitted alternately through its insect and animal hosts.[10] However, individual gene segments undergo different selective pressures and some, particularly segments 4 and 5, are subject to positive selection.[10]

Genetic diversification of BTV occurs primarily through reassortment of the gene segments during co-infection of the host cell. Reassortment can lead to a rapid shift in phenotypes independent of the slow rate of mutation. During this process, gene segments are not randomly reassorted. Rather, there appears to be a mechanism for selecting for or against certain segments from the parental serotypes present.[11] However, this selective mechanism is still poorly understood.

Epidemiology

The molecular epidemiology of Bluetongue virus in Europe since 1998: routes of introduction of different serotypes and individual virus strains

Bluetongue has been observed in Australia, the US, Africa, the Middle East, Asia, and Europe. An outline of the transmission cycle of BTV is illustrated in article Parasitic flies of domestic animals.

Its occurrence is seasonal in the affected Mediterranean countries, subsiding when temperatures drop and hard frosts kill the adult midge vectors.[12] Viral survival and vector longevity is seen during milder winters.[13] A significant contribution to the northward spread of bluetongue disease has been the ability of C. obsoletus and C.pulicaris to acquire and transmit the pathogen, both of which are spread widely throughout Europe. This is in contrast to the original C.imicola vector, which is limited to North Africa and the Mediterranean. The relatively recent novel vector has facilitated a far more rapid spread than the simple expansion of habitats north through global warming.[14]

In August 2006, cases of bluetongue were found in the Netherlands, then Belgium, Germany, and Luxembourg.[15][16] In 2007, the first case of bluetongue in the Czech Republic was detected in one bull near Cheb at the Czech-German border.[17] In September 2007, the UK reported its first ever suspected case of the disease, in a Highland cow on a rare-breeds farm near Ipswich, Suffolk.[18] Since then, the virus has spread from cattle to sheep in Britain.[19] By October 2007, bluetongue had become a serious threat in Scandinavia and Switzerland[20] and the first outbreak in Denmark was reported.[21] In autumn 2008, several cases were reported in the southern Swedish provinces of Småland, Halland, and Skåne,[22] as well as in areas of the Netherlands bordering Germany, prompting veterinary authorities in Germany to intensify controls.[23] Norway had its first finding in February 2009, when cows at two farms in Vest-Agder in the south of Norway showed an immune response to bluetongue.[24] Norway was declared free of the disease in 2011.[25] As of November 2023, cases of bluetongue have been recorded in Belgium, Germany, the Netherlands, France, Spain, and the UK.[26]

Although the disease is not a threat to humans, the most vulnerable common domestic ruminants are cattle, goats, and especially, sheep.

Overwintering

A puzzling aspect of BTV is its survival between midge seasons in temperate regions. Adults of Culicoides are killed by cold winter temperatures, and BTV infections typically do not last for more than 60 days, which is not long enough for BTV to survive until the next spring. It is believed that the virus somehow survives in overwintering midges or animals. Multiple mechanisms have been proposed. A few adult Culicoides midges infected with BTV may survive the mild winters of the temperate zone. Some midges may even move indoors to avoid the cold temperature of the winter. Additionally, BTV could cause a chronic or latent infection in some animals, providing another means for BTV to survive the winter. BTV can also be transmitted from mother to fetus. The outcome is abortion or stillbirth if fetal infection occurs early in gestation and survival if infection occurs late. However infection at an intermediate stage, before the fetal immune system is fully developed, may result in a chronic infection that lingers until the first months after birth of the lamb. Midges then spread the pathogen from the calves to other animals, starting a new season of infection.[27]

Climate change

This section is an excerpt from Culicoides imicola § Role of climate change.[edit]
Traditionally, Culicoides imicola has been found in subtropical Asia and Africa. However, due to climate change, they have spread all the way to Europe and as far as Sweden.[28] The increase in temperature has positively impacted C. imicola distribution, which has raised concern in the spread of disease across central Europe as the flies make their way northward.[29][30] Without a significant improvement in epidemiological control measures, what is currently considered an once-in-20-years outbreak of bluetongue would occur as frequently as once in five or seven years by midcentury under all but the most optimistic climate change scenario.[31]: 747 

Treatment and prevention

Prevention is effected via quarantine, inoculation with live modified virus vaccine, and control of the midge vector, including inspection of aircraft.

Livestock management and insect control

Vaccines

Protection by live attenuated vaccines (LAVs) are serotype specific. Multiserotype LAV cocktails can induce neutralizing antibodies against unincluded serotypes, and subsequent vaccinations with three different pentavalent LAV cocktails induce broad protection. These pentavalent cocktails contain 15 different serotypes in total: serotypes 1 through 14, as well as 19.[32]

Immunization with any of the available vaccines, though, precludes later serological monitoring of affected cattle populations, a problem that could be resolved using next-generation subunit vaccines.[33]

In January 2015, Indian researchers launched a vaccine named Raksha Blu that is designed to protect livestock against five strains of the bluetongue virus prevalent in the country.[34]

History

Although bluetongue disease was already recognized in South Africa in the early 19th century, a comprehensive description of the disease was not published until the first decade of the 20th century.[35] In 1906, Arnold Theiler showed that bluetongue was caused by a filterable agent. He also created the first bluetongue vaccine, which was developed from an attenuated BT[36] V strain.[37] For many decades, bluetongue was thought to be confined to Africa. The first confirmed outbreak outside of Africa occurred in Cyprus in 1943.[35] Recently, a vessel owned by Khalifeh Livestock Trading and managed by Talia Shipping Line, both based in Lebanon, has been denied right to dock in Spain, as it has about 895 male calves suspected to be infected by bluetongue disease.[36][38]

African horse sickness is related to bluetongue and is spread by the same midges (Culicoides species). It can kill the horses it infects and mortality may go as high as 90% of the infected horses during an epidemic.[39]

Epizootic hemorrhagic disease virus is closely related and crossreacts with Bluetongue virus on many blood tests.

References

  1. ↑ "Q&A: Bluetongue disease". BBC. 2008-09-17. Retrieved 2010-01-01.
  2. ↑ Mauroy A, Guyot H, De Clercq K, Cassart D, Thiry E, Saegerman C (April 2008). "Bluetongue in captive yaks". Emerging Infectious Diseases. 14 (4): 675–676. doi:10.3201/eid1404.071416. PMC 2570917. PMID 18394296.
  3. 1 2 3 Roy P (2008). "Molecular Dissection of Bluetongue Virus". Animal Viruses: Molecular Biology. Caister Academic Press. pp. 305–54. ISBN 978-1-904455-22-6.
  4. ↑ McGrath M (29 September 2007). "'Dancing' disease set for long run". BBC News. Retrieved 2008-10-24.
  5. ↑ Handbook on Animal Eiseases in the Tropics (3rd ed.). London: British Veterinary Association. 1976. ISBN 978-0-901028-10-5.
  6. ↑ Jensen R, Swift BL (1982). Diseases of Sheep. Philadelphia: Lea and Febiger. ISBN 978-0-8121-0836-1.
  7. 1 2 Rodríguez-Martín D, Louloudes-Lázaro A, Avia M, Martín V, Rojas JM, Sevilla N (July 2021). "The Interplay between Bluetongue Virus Infections and Adaptive Immunity". Viruses. 13 (8): 1511. doi:10.3390/v13081511. PMC 8402766. PMID 34452376.
  8. 1 2 Roy P (2008). "Functional mapping of bluetongue virus proteins and their interactions with host proteins during virus replication". Cell Biochemistry and Biophysics. 50 (3): 143–157. doi:10.1007/s12013-008-9009-4. PMID 18299997. S2CID 984334.
  9. ↑ Rossmann MG, Tao Y (March 1999). "Courageous science: structural studies of bluetongue virus core". Structure. 7 (3): R43–R46. doi:10.1016/s0969-2126(99)80031-8. PMID 10368304.
  10. 1 2 3 Kopanke JH, Lee JS, Stenglein MD, Mayo CE (September 2020). "The Genetic Diversification of a Single Bluetongue Virus Strain Using an In Vitro Model of Alternating-Host Transmission". Viruses. 12 (9): 1038. doi:10.3390/v12091038. PMC 7551957. PMID 32961886.
  11. ↑ Kopanke J, Lee J, Stenglein M, Mayo C (February 2021). "In Vitro Reassortment between Endemic Bluetongue Viruses Features Global Shifts in Segment Frequencies and Preferred Segment Combinations". Microorganisms. 9 (2): 405. doi:10.3390/microorganisms9020405. PMC 7920030. PMID 33669284.
  12. ↑ Purse BV, Mellor PS, Rogers DJ, Samuel AR, Mertens PP, Baylis M (February 2005). "Climate change and the recent emergence of bluetongue in Europe". Nature Reviews. Microbiology. 3 (2): 171–181. doi:10.1038/nrmicro1090. PMID 15685226. S2CID 62802662.
  13. ↑ "Bluetongue – Europe (51)". International Society for Infectious Diseases. 2007-10-30. Archived from the original on December 26, 2007. Retrieved 2007-10-31.
  14. ↑ Baylis M, Caminade C, Turner J, Jones AE (August 2017). "The role of climate change in a developing threat: the case of bluetongue in Europe". Revue Scientifique et Technique. 36 (2): 467–478. doi:10.20506/rst.36.2.2667. PMID 30152470.
  15. ↑ "Blue Tongue confirmed in Belgium and Germany" (Press release). European Commission. 2006-08-21. Retrieved 2006-08-21.
  16. ↑ "Lethal horse disease knocking on Europe's door" (Press release). Horsetalk.co.nz. 2007-03-28. Retrieved 2007-03-27.
  17. ↑ "Bluetongue dobývá Evropskou unii". Agroweb. 2008-02-19. Archived from the original on 2009-03-06. Retrieved 2008-05-29.
  18. ↑ "Bluetongue disease detected in UK". BBC News Online. 2007-09-22. Retrieved 2007-09-22.
  19. ↑ Gray R (2007-10-14). "Bluetongue spreads from cattle to sheep". London: Telegraph.co.uk. Retrieved 2007-10-15.
  20. ↑ "Bluetongue – Europe (50)". International Society for Infectious Diseases. 2007-10-30. Archived from the original on December 26, 2007. Retrieved 2007-10-31.
  21. ↑ "Bluetongue outbreak detected in Denmark – EU". Reuters. 13 October 2007.
  22. ↑ "Blue tongue outbreak spreads south". Thelocal.se. 2008-09-24. Retrieved 2008-09-24.
  23. ↑ Mehlhorn H, Walldorf V, Klimpel S, Schaub G, Kiel E, Focke R, et al. (August 2009). "Bluetongue disease in Germany (2007-2008): monitoring of entomological aspects". Parasitology Research. 105 (2): 313–319. doi:10.1007/s00436-009-1416-y. PMID 19322587. S2CID 35616241.
  24. ↑ "Blåtunge påvist i Norge" [Bluetongue detected in Norway]. Veterinærinstituttet [Norway National Veterinary Institute] (in Norwegian). 24 February 2009. Archived from the original on 2009-03-06.
  25. ↑ "Bluetongue serotype 8 outbreak in Norway". www.vetinst.no. Retrieved 2023-12-12.
  26. ↑ "29 November 2023: updated outbreak assessment for Bluetongue virus in Europe". GOV.UK. Retrieved 2023-12-12.
  27. ↑ Wilson A, Darpel K, Mellor PS (August 2008). "Where does bluetongue virus sleep in the winter?". PLOS Biology. 6 (8): e210. doi:10.1371/journal.pbio.0060210. PMC 2525685. PMID 18752350.
  28. ↑ Mellor, P. S., J. Boorman, and M. Baylis. “Culicoides Biting Midges: Their Role as Arbovirus Vectors.” Annual Review of Entomology 45, no. 1 (2000): 307–40. https://doi.org/10.1146/annurev.ento.45.1.307.
  29. ↑ Gao, Hongyan; Wang, Long; Ma, Jun; Gao, Xiang; Xiao, Jianhua; Wang, Hongbing (29 October 2021). "Modeling the current distribution suitability and future dynamics of Culicoides imicola under climate change scenarios". PeerJ Life & Environment. 9: e12308. doi:10.7717/peerj.12308. PMC 8559603. PMID 34760364.
  30. ↑ Bett, B.; Kiunga, P.; Gachohi, J.; Sindato, C.; Mbotha, D.; Robinson, T.; Lindahl, J.; Grace, D. (23 January 2017). "Effects of climate change on the occurrence and distribution of livestock diseases". Preventive Veterinary Medicine. 137 (Pt B): 119–129. doi:10.1016/j.prevetmed.2016.11.019. PMID 28040271.
  31. ↑ Kerr R.B., Hasegawa T., Lasco R., Bhatt I., Deryng D., Farrell A., Gurney-Smith H., Ju H., Lluch-Cota S., Meza F., Nelson G., Neufeldt H., Thornton P., 2022: Chapter 5: Food, Fibre and Other Ecosystem Products. In Climate Change 2022: Impacts, Adaptation and Vulnerability [H.-O. Pörtner, D.C. Roberts, M. Tignor, E.S. Poloczanska, K. Mintenbeck, A. Alegría, M. Craig, S. Langsdorf, S. Löschke,V. Möller, A. Okem, B. Rama (eds.)]. Cambridge University Press, Cambridge, United Kingdom and New York, NY, US, pp. 1457–1579 |doi=10.1017/9781009325844.012
  32. ↑ van Rijn PA (2019-11-21). "Prospects of Next-Generation Vaccines for Bluetongue". Frontiers in Veterinary Science. 6: 407. doi:10.3389/fvets.2019.00407. PMC 6881303. PMID 31824966.
  33. ↑ Anderson J, Hägglund S, Bréard E, Comtet L, Lövgren Bengtsson K, Pringle J, et al. (August 2013). "Evaluation of the immunogenicity of an experimental subunit vaccine that allows differentiation between infected and vaccinated animals against bluetongue virus serotype 8 in cattle". Clinical and Vaccine Immunology. 20 (8): 1115–1122. doi:10.1128/CVI.00229-13. PMC 3754508. PMID 23720365.
  34. ↑ Staff Reporter (2015-01-08). "Vaccine for bluetongue disease launched". The Hindu.
  35. 1 2 Mertens P (2009). Bluetongue (Biology of Animal Infections) (1 ed.). Academic Press. pp. 7–21. ISBN 978-0123693686.
  36. 1 2 Kevany SM (2021-02-25). "Cattle stranded at sea 'face immediate slaughter' if ship docks in Spain, says manager". The Guardian. ISSN 0261-3077. Retrieved 2021-02-28.
  37. ↑ Maclachlan NJ (November 2011). "Bluetongue: history, global epidemiology, and pathogenesis". Preventive Veterinary Medicine. 102 (2): 107–111. doi:10.1016/j.prevetmed.2011.04.005. PMID 21570141.
  38. ↑ Kevany S, Kassam A (27 February 2021). "Cattle stranded on ship in Spain must be destroyed, say vets". The Guardian. Retrieved 26 July 2022.
  39. ↑ Weyer C (October 2021). "African Horse Sickness – Clinical Findings and Lesions". The Merck Veterinary Manual.

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