The Bournemouth to Birmingham route is a part of the CrossCountry network, linking Bournemouth to Birmingham. The route consists of parts of several lines, and trains running the full length of the route are run by CrossCountry. It is also used in parts by Avanti West Coast, Chiltern Railways, Great Western Railway, South Western Railway and West Midlands Trains . After joining the Cross Country Route at Birmingham, trains proceed to Manchester, Glasgow, Edinburgh or even Aberdeen.
- The southern terminus at Bournemouth
- Basingstoke, where the line leaves the South West Main Line
- Reading, trains usually reverse in the platforms to the left or behind the GWR building
- The station at Oxford on the Cherwell Valley Line
- Leamington Spa, where trains leave the Chiltern Main Line
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