Frylock develops a spherical supercomputer/game console that he calls the OoGhiJ MIQtxxXA (Klingon for "superior galactic intelligence"), which is accidentally sent back in time. It ends up in the hands of a caveman, Oog, who gains super-intelligence and longevity with the help of the computer, then takes out a patent on it.

The Aqua Teens discover Travis, a spore that uses his "tongue" to penetrate Master Shake's skull and use his body to communicate. He has come to Earth to find a good job with a 401(k) and health insurance. The group decides to teach him English so he can communicate better. Unfortunately, the spore learns the hard way as Meatwad uses an "instructional tape" from Carl, which is a really a self-help tape for picking up women. He manages to learn English but with tainted grammar, incessant cursing, and being rude, much to Frylock's anger.

The Aqua Teens participate in a trivia game at a local bar as team versus the one and only but smart Wayne 'The Brain' McClane. The team loses again, Meatwad having put down Backstreet Boys on half their answers, Shake putting down even far wrong answers, and Frylock lacking knowledge in sports. Frylock, sick of losing to Wayne, decides to turn it all around for the next game by using the Ludovico technique on Shake and Meatwad to boost their knowledge via a huge DVD Frylock loaded. The experiments works only for Shake, and when Frylock realizes he forgot to put sports on the colossal disc, he recruits Carl.

Master Shake discovers a cavern where a cursed sandwich known as "the Broodwich" rests. Every time he ingests a bite of the sandwich, he is sent to a hellish dimension for a few seconds, and is warned by a disembodied voice and Frylock that anyone who eats the entire sandwich will be trapped there. After trying to fight his temptation, Shake continues to eat the sandwich, but is not trapped in the other dimension, because he removed tomatoes from the sandwich. The voice eventually offers him free brain surgery, after which Shake eats the tomatoes and is sent to the other dimension.

Note: The alternate dimension scenes are an acknowledged homage to Don Hertzfeldt, Hertzfeldt's films, and Rejected in particular.^[4]

The Plutonians, aboard their spaceship, have successfully traveled "eons" through use of their Stargate-type device called the Fargate (Oglethorpe insists theirs is different, as he does not want to get sued). They state that the purpose of the gate is to steal cable from the Aqua Teens. The only problem is that they have no chance to change the channel, because they have no remote control. However, the Plutonians have created their own, something they call the Universal Remonster - a small remote control creature with fur. They plan to use him to control their programming, but he quickly escapes.

The Universal Remonster begins to control the Aqua Teens' TV, and they have no idea what's happening. Finally, Frylock investigates, and turns off the TV several times, only to have it continually turn back on. Frylock then unplugs it to see what will happen, and the Universal Remonster comes into view and plugs the TV back in. The Universal Remonster becomes Shake's personal plaything. Although the Remonster is meant for TV, Shake uses it as a device to torture Meatwad.

Frylock asks Carl to test out his latest invention: An environmentally-friendly Toilet powered by a jet-engine to dispose of waste. At first, Carl is unwilling to try out the toilet because of it being on his front lawn but changes his mind after Frylock tells him the toilet comes with an invisibility device. Then Frylock tells Carl to test it out, to which Carl tells him he doesn't have to 'go', so Frylock gives him some fiber-tablets and espresso as a 'free gift'. Frylock goes back to his house where he and Meatwad watch Carl through binoculars to see how the toilet works so Frylock can apply for a patent.

Meatwad informs Frylock that Carl won't 'go' in his yard and that he'll go inside, in which we discover Frylock has locked Carl's door. Carl finally sits on the toilet to 'go' and causes Master Shake to be traumatized from seeing him, revealing Frylock lied about installing an invisibility device. After Carl is done 'going', he flushes the toilet and is sucked into the bowl by the engine leaving only his head. As the Aqua Teens examine the carnage, Meatwad says "We have the technology. We can rebuild him." Meatwad and Master Shake then Bungie-cord Carl's head to a tree and tape his clothes to it, inspiring Frylock to genetically restore Carl's body.

Master Shake then steals a corpse from the cemetery for Frylock to attach Carl's head to, while Meatwad tries to learn how to swear. When Carl awakens, he discovers that Frylock and Master Shake have attached his head to the body of a deceased elderly African-American, and the body rejects his head by trying to rip Carl's head off it, resulting in Frylock deactivating Carl and the body. Next, Frylock orders organs from a medical bank to reconstruct Carl's body, but discovers the medical bank only sent eyeballs, resulting in Carl becoming horrified by his appearance and enraged at what Frylock has done to him, causing Carl to attempt to strangle Frylock before Meatwad deactivates him. Then, Frylock builds a cybernetic military-gade robotic body for Carl, but changes his mind when he realizes that Carl will most definitely kill him if he is activated.

Carl has installed an ultra high-tech security system to keep the Aqua Teens out of his pool. Because of the brightness, his security grid happens to be seen from space, attracting the attention of two space aliens DP and Skeeter, members of a space college fraternity. After a drunken crash course in space, they head for the bright red lights and crash-land in the neighborhood with a frat pledge in tow, drunkenly causing trouble and DP unsuccessfully soliciting sex from Frylock and Meatwad, causing Shake to question his sexuality. When DP passes out and Skeeter accidentally leaves him behind in the ship, Frylock must find a way to get him back to where he came from.

It's Meatwad's birthday, and Master Shake can't stand "Happy Birthday To You". He commissioned a new heavy-metal song co-written by him, Zakk Wylde, and Geddy Lee titled "Spirit Journey Formation Anniversary," which is intended to replace the original birthday song. Frylock is shocked discover that the entire endeavor cost $1.4 million, Shake having bought expensive things on Zakk's charge and expects the song to be a hit so he can cash in royalties to pay off the project. Unfortunately, not only do Frylock and Meatwad hate the song, nobody else likes nor wants to buy it, putting Shake in deep financial trouble. After a failed attempt to sell the house, and a furious Zakk Wylde showing up and injuring him, Shake has Zakk play the song at a pizza place along with two scorpion animatronics in a bid to pay off everything, which only makes matters worse.

The Wisdom Cube, a cube from outer space, comes to the Aqua Teens' yard. It claims to have all of the wisdom in the universe, but it does little to reinforce its claim. Shake quickly warms up to him, but soon gets annoyed by his antics. Frylock asks him to solve a paradox, but all the Wisdom Cube says is "Yuh-huh". When they try to go out to the pool, Meatwad rolls back to listen to the cube's outrageous stories. Shake and Frylock discuss if Meatwad is smart enough to get out of the conversations, and in the middle of their conversation, Shake exclaims "For the love of all that's holy, there's another one! " After a small conversation, the second cube apologizes and claims he's the "real" Wisdom Cube and the original cube is his cousin: The Dumbassahedratron. Frylock asks the real cube the paradox, but the cube leaves him with a flaming bag that contains "the answer". After some convincing by Shake and the two cubes, he puts the bag out, only to have his fry covered in dog crap. The real cube tries to convince him if he wants "the final final answer" he should put it in his mouth. The cubes fly up, only to be killed by a passing helicopter.

It's Halloween night in South Jersey, and the Aqua Teens are gearing up for the holiday by dressing up...except Master Shake, of course. Frylock is a sailor on the Ship of the Damned, and Meatwad is the Incredible Plum (a take off on the Incredible Hulk, with Meatwad being painted purple). Shake, being the person he is, can't resist making fun of their costumes.

While Frylock is finishing getting ready, Shake and Meatwad are met by a creature that's a cross between an onion and a spider, who tries to scare people through use of a triple-head electric razor. The only thing it gets is ridicule from Shake and Frylock.

Finally, the onion/spider reveals who he is: his name is Willie Nelson, and he lives in the attic. He's also looking for his mail, which he hasn't gotten for a while. Frylock admits to throwing said mail away, which angers Willie and causes him to throw the Aqua Teens' TV out a window.

After making fun of Willie's methods (Shake calls the laid back spider "The Gayest Monster since Gay Came to Gaytown" and says he should star in a musical called "The Texas Chainsaw Mascara"), Shake decides to remake the laid back onion/spider into a killing machine, in the image of a serial killer.

During the course of this, Shake has Willie assume the persona of Blood Feast Island Man, and try to scare Carl next door. After Willie fails for the first time, Shake succeeds in scaring Carl by throwing Meatwad at him.

Shake's next try to make Willie scary is to have him go next door and threaten Carl with chainsaws, with him saying, "Nice head. I think I'll take it." This fails again, as Willie runs out of luck when his chainsaws become unplugged thanks to the extension cords powering them falling off. When this happens, Carl comes out angrily and asks "What!?" to which he can only reply "What are you doing here?" which Carl answers by saying "I live here, asshole!". Carl then goes back to the Aqua Teens' house and throws Meatwad at Shake, who is flipping out because Willie didn't scare Carl.

Shake and Willie decide to go with one final prank to scare Carl. Shake hooks up a huge electrical generator to Carl's door using jumper cables, while Willie is waiting with a cement mixer full of blood to dump on Carl once the electricity shocks him unconscious. However, the plan doesn't go as well as hoped, as Carl scares Shake with Meatwad's Incredible Plum mask, causing Shake to fall into the generator and get the blood poured on him.

After going back up to the attic, Frylock informs Willie that he has some of his mail. After Willie urges him to bring it up, we find out the horrible truth about him- he is an actual killer who stores his bodies in the Aqua Teens' attic. Frylock and Shake are instantly horrified, and a late entering Carl gets his arms ripped off by Willie, who drinks his blood and calls it juice. The Aqua Teens run off and seal the attic, presumably locking Willie in there forever (with a screaming Carl).

Carl shows up at the Aqua Teen's door to reveal that his house is infested with termites. He mutters that he won't sign for any more packages with "Congo" written in blood. Meatwad hurries over to receive a termite of his own. Throughout all this, Carl seems to be level-headed, a trait that he does not usually portray. He reveals that he has gotten a wig, and it cost a substantial amount.

Carl is later reading a magazine on how to pick up girls, when Shake suddenly appears in his room. Carl tries to remove the wig and place it upon a mannequin head, but finds it stuck to his head. Carl is distracted by Shake, who is rummaging through his belongings. When Carl leaves, his mannequin head grows fangs and devilish eyes.

Carl wakes up to Shake standing in his room. Carl's hair has now changed color from brown to black, and has become much curlier. Shake is quick to anger Carl, and is then thrown out the window. As Carl leaves the room, his mannequin head speaks to a floating head with a clown wig on. They argue, and then part ways as Carl reenters the room.

Later that day, Carl brings home a prostitute. The Aqua Teens follow him, and through the holes in Carl's wall, watches as Carl plays an air guitar solo, only to be interrupted by the Aqua Teens. As he steps outside to speak with them, his hair gains more mass and becomes red. After they argue, he proceeds to have sex with the now passed-out prostitute.

At the Aqua Teen's house, an examination of Carl's hair reveals that he is infected with Clown DNA. The prostitute runs out screaming, and Carl follows with white skin dotted with purple blotches, a clown nose, huge feet, and a clown car. He goes to the Aqua Teen's house for help. Frylock attempts to cut Carl's hair off, but it only grows back and lands on Meatwad. Meatwad shortly develops the symptoms that Carl had, and Carl walks out with a balloon resembling a shotgun, asking God to kill him. Frylock freezes him until he can find a cure.

At the end of this episode (67 years later), an apocalyptic future is depicted, and Carl, being used as a coat rack (and still in a frozen state), is knocked over and presumably killed. The now over-the-hill Aqua Teens struggle to remember Carl's name, and the episode ends with Frylock yelling at Shake and Meatwad exclaiming that he has shattered his hip.

Meatwad rolls over to Carl's with a message, which he is unable to remember due to his limited intelligence, so he roots around in his meat looking for the note he wrote as a reminder, pulling out his dolls Squirrelly and a decapitated Jiggle Billy in the process. Eventually he finds the right note, which is a Thanksgiving invitation.

Since they aren't legally US citizens yet, the Aqua Teens have Thanksgiving a week past the actual holiday and invite Carl over to share in the festivities (though Carl decides to have dinner outside for the purpose of having witnesses). However, the dinner is interrupted when a mechanical turkey bursts into the home and grabs Carl by the throat (before tossing him out the window when Frylock asks the turkey to put him down). The turkey says his name is Turkitron and claims to be sent from the year 9595 to save the great-great-great-great grandfather of the turkey "Goblox," who is supposed to save the turkeys from the chicken overlords. Unfortunately, as Frylock points out, the turkey is already dead and about to be served as food.

Turkitron then tells a series of long tales about subjects ranging from the chicken overlords to the banning of taco pie to the claim that Carl is, in fact, a chicken mercenary sent from 9595 to stop the mission. All the while, Turkitron downs taco pie and wine, then attempts to find a time rift through which he will travel with the dinner turkey to a time before his killing. The turkey's mannerisms lead the ATHF to believe that this turkey is somehow related to the Cybernetic Ghost of Christmas Past from the Future (which Turkitron admits he took the form of in his first appearance). They also find it odd that he carries all his belongings in a plastic bag, including socks, which Turkitron claims are laser-guided weapons.

When Turkitron passes out drunk from the wine (and after destroying the ATHF's television), Frylock ties up the turkey and explores his head with a blowtorch. After Frylock adjusts some crossed wires, Turkitron starts doing the Hustle. Master Shake enters with a newspaper (to show a pantyhose ad), but Frylock discovers an article that states that Turkitron is actually a defective toy called the "Hustlin' Tom Turkey" and that 5,000 were made. At that moment, a large number of turkey robots (perhaps the other 4,999 turkeys) show up at the ATHF's door. Shake directs them to Carl's house, who opens the door while munching on a turkey leg. When asked what it is, Carl begins to say, "This is your great-great-great...", and the turkeys take aim with their laser-guided socks. Just before the turkeys fire on Carl, he says, "You mother-"

Master Shake nearly destroys the house by leaving garbage everywhere and planting land mines all over. He especially trashes Frylock's room, closing up the doorway with bricks and installed a camera system for it to show on the inside the collateral damage he's done to a horrified Frylock. Completely fed up with everything, Frylock abandons his friendship with Shake and moves to a condominium. Without Frylock's stabilizing influence and actions, the house falls into total chaos with Shake burning styrofoam, stockpiling chicken carcasses, abusing and dominating Meatwad. They both, along with Carl, get conjunctivitis in which their eyelids getting so puffy, they can barely see.

Master Shake destroys another TV, which happens to be their last one. Shake and Meatwad then discover that Frylock had been cloning the TVs with his cloner. and tired of doing so he plans to stop. He explains that if something is cloned too many times, the molecular structure begins to break down and unusual events will occur. After Meatwad makes a play for sympathy from Frylock, saying that he can't face the day without his TV, he decides to clone another TV. But true to Frylock's warning, odd things began to happen regarding the TV, and chaos ensues when Shake takes advantage of money with the cloner.

The Mooninites have gathered a bunch of their villain friends for one final push towards eliminating the Aqua Teens. However, they do not succeed, and much of their group is eliminated from the meeting. Only the Rabbot, the Mooninites, Mothmonsterman, Happy Time Harry, the Cybernetic Ghost of Christmas Past from the Future, and Major Shake get to South Jersey. They plan to shove "The Screw of Damnation" into the Hunger Force's heads. When the Mooninites were asked how they would get it in there, the Mooninites planned (They planned on having the others do it) on giving the Hunger Force a Post-It note saying "Stay Still." Early on the episode, they decide to make a cool group name. The brownies suggest "Click-Click-Click-Click..." and they finally settle on the Rabbot's idea, "Monday Tuesday Wednesday Thursday Friday Saturday Sunday..." Meanwhile, the Plutonians, who were not invited because they were "teh s uck", have formed their own group consisting of them and a headless Jiggle Billy.