CCR3
Identifiers
AliasesCCR3, CC-CKR-3, CD193, CKR3, CMKBR3, C-C motif chemokine receptor 3, CKR 3, C C CKR3
External IDsOMIM: 601268 MGI: 104616 HomoloGene: 20436 GeneCards: CCR3
Orthologs
SpeciesHumanMouse
Entrez

1232

12771

Ensembl

ENSG00000183625

ENSMUSG00000035448

UniProt

P51677

P51678

RefSeq (mRNA)

NM_001164680
NM_001837
NM_178328
NM_178329

NM_009914

RefSeq (protein)

NP_001158152
NP_001828
NP_847898
NP_847899

NP_034044

Location (UCSC)Chr 3: 46.13 – 46.27 MbChr 9: 123.82 – 123.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

C-C chemokine receptor type 3 is a protein that in humans is encoded by the CCR3 gene.[5]

CCR3 has also recently been designated CD193 (cluster of differentiation 193).

Function

The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils,[6] and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway, and possibly at sites of parasitic infection. It is also known to be an entry co-receptor for HIV-1, enabling viral infection in cells that also express CD4, the receptor of HIV-1.[7] This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described.[5]

See also

Interactions

CCR3 (gene) has been shown to interact with CCL5.[8][9][10]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000183625 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035448 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: CCR3 chemokine (C-C motif) receptor 3".
  6. ↑ •Murphy KM, P Travers, M Walport (Eds.) (2010) Janeway's Immunobiology. 8th Edition. New York:Taylor & Francis, Inc.
  7. ↑ Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, et al. (1996). "The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates". Cell. 85 (7): 1135–1148. doi:10.1016/s0092-8674(00)81313-6. PMID 8674119.
  8. ↑ Ponath PD, Qin S, Post TW, Wang J, Wu L, Gerard NP, Newman W, Gerard C, Mackay CR (1996). "Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils". J. Exp. Med. 183 (6): 2437–48. doi:10.1084/jem.183.6.2437. PMC 2192612. PMID 8676064.
  9. ↑ Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS (May 1996). "Cloning, expression, and characterization of the human eosinophil eotaxin receptor". J. Exp. Med. 183 (5): 2349–54. doi:10.1084/jem.183.5.2349. PMC 2192548. PMID 8642344.
  10. ↑ Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J (July 2001). "Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils". Eur. J. Immunol. 31 (7): 2170–8. doi:10.1002/1521-4141(200107)31:7<2170::aid-immu2170>3.0.co;2-d. PMID 11449371.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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