CIR (gene)

CIR1
Identifiers
Aliases	CIR1, CIR, corepressor interacting with RBPJ, 1, corepressor interacting with RBPJ
External IDs	OMIM: 605228 MGI: 1914185 HomoloGene: 3589 GeneCards: CIR1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	174,395,712 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	73,143,045 bp
RNA expression pattern
	Top expressed in
	monocyte; ; Achilles tendon; ; sural nerve; ; right uterine tube; ; right lung; ; gastric mucosa; ; blood; ; skin of abdomen; ; body of pancreas; ; rectum;
	Top expressed in
	bone marrow; ; testicle; ; secondary oocyte; ; ovary; ; ganglionic eminence; ; lung; ; thymus; ; proximal tubule; ; kidney; ; lens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; protein binding; transcription corepressor activity; protein kinase binding; protein-containing complex binding;
Cellular component	cytoplasm; histone deacetylase complex; cytoskeleton; nucleus; microtubule organizing center; nuclear speck; centrosome; protein-containing complex;
Biological process	mRNA processing; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; RNA splicing; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	9541
	66935
	ENSG00000138433
	ENSMUSG00000041777
	Q86X95
	Q9DA19
	NM_199075; NM_004882
	NM_025854
	NP_004873
	NP_080130
	Wikidata
View/Edit Human	View/Edit Mouse

Corepressor interacting with RBPJ 1 is a protein that in humans is encoded by the CIR1 gene.^[5]^[6]^[7]^[8]

Interactions

CIR (gene) has been shown to interact with SNW1.^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000138433 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041777 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Maita H, Kitaura H, Ariga H, Iguchi-Ariga SM (Feb 2005). "CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing". Experimental Cell Research. 303 (2): 375–87. doi:10.1016/j.yexcr.2004.10.012. PMID 15652350.
↑ Zhang J, Chen H, Weinmaster G, Hayward SD (Mar 2001). "Epstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchIC". Journal of Virology. 75 (6): 2946–56. doi:10.1128/JVI.75.6.2946-2956.2001. PMC 115921. PMID 11222720.
↑ Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD (Jan 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America. 96 (1): 23–8. Bibcode:1999PNAS...96...23H. doi:10.1073/pnas.96.1.23. PMC 15086. PMID 9874765.
↑ "Entrez Gene: CIR CBF1 interacting corepressor".
↑ Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (Feb 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology. 74 (4): 1939–47. doi:10.1128/JVI.74.4.1939-1947.2000. PMC 111672. PMID 10644367.

External links

Human CIR1 genome location and CIR1 gene details page in the UCSC Genome Browser.

DuBridge RB, Tang P, Hsia HC, Leong PM, Miller JH, Calos MP (Jan 1987). "Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system". Molecular and Cellular Biology. 7 (1): 379–87. doi:10.1128/mcb.7.1.379. PMC 365079. PMID 3031469.
Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (Feb 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology. 74 (4): 1939–47. doi:10.1128/JVI.74.4.1939-1947.2000. PMC 111672. PMID 10644367.
Krithivas A, Young DB, Liao G, Greene D, Hayward SD (Oct 2000). "Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells". Journal of Virology. 74 (20): 9637–45. doi:10.1128/JVI.74.20.9637-9645.2000. PMC 112396. PMID 11000236.
Zhou S, Hayward SD (Sep 2001). "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex". Molecular and Cellular Biology. 21 (18): 6222–32. doi:10.1128/MCB.21.18.6222-6232.2001. PMC 87339. PMID 11509665.
Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (Oct 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000138433 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041777 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15652350-5] Maita H, Kitaura H, Ariga H, Iguchi-Ariga SM (Feb 2005). "CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing". Experimental Cell Research. 303 (2): 375–87. doi:10.1016/j.yexcr.2004.10.012. PMID 15652350.

[pmid11222720-6] Zhang J, Chen H, Weinmaster G, Hayward SD (Mar 2001). "Epstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchIC". Journal of Virology. 75 (6): 2946–56. doi:10.1128/JVI.75.6.2946-2956.2001. PMC 115921. PMID 11222720.

[pmid9874765-7] Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD (Jan 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America. 96 (1): 23–8. Bibcode:1999PNAS...96...23H. doi:10.1073/pnas.96.1.23. PMC 15086. PMID 9874765.

[entrez-8] "Entrez Gene: CIR CBF1 interacting corepressor".

[pmid10644367-9] Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (Feb 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology. 74 (4): 1939–47. doi:10.1128/JVI.74.4.1939-1947.2000. PMC 111672. PMID 10644367.

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Interactions

References

External links

Further reading