CTRL or Ctrl may refer to several things:
- Channel Tunnel Rail Link, often referred to as High Speed 1 (HS1), UK's first high speed railway line over 200 km/h (125 mph) that opened in sections between 2003 and 2007
- Control key, an input button present on most computer keyboards
- CTRL (gene), a gene that in humans encodes the enzyme chymotrypsin-like protease CTRL-1
- Ctrl (web series), an American comedy web series from NBC
- Ctrl (Derek Webb album), a 2012 album by singer-songwriter Derek Webb
- Ctrl (SZA album), a 2017 album by singer-songwriter SZA
- CTRL (TV series), a 2021 Singaporean television drama
- Cyberoam Threat Research Labs, a facility of Cyberoam
- The stock symbol for Control4
See also
- Control-Alt-Delete (disambiguation)
- CNTRL, protein that in humans is encoded by the CNTRL gene
- CNTRL: Beyond EDM, a North American educational initiative, centered on electronic dance music
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