Cassius Marcellus Clay may refer to:
- Cassius Marcellus Clay (politician) (1810–1903), American politician and abolitionist
- Cassius Marcellus Clay Sr. (1912–1990), American painter and musician, named after the abolitionist, father of the boxer
- Cassius Marcellus Clay Jr. or Muhammad Ali (1942–2016), American boxer
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