Circumventricular organs
Identifiers
MeSHD066280
NeuroLex IDnlx_anat_20090312
FMA84081
Anatomical terms of neuroanatomy
Wikimedia Commons has media related to Circumventricular organs.
Human brain circumventricular organs in detail.
Human brain: Circumventricular organs - General
Human brain: 3rd and 4th ventricles
Human brain: Organum vasculosum
Human brain: Subfornical organ
Human brain: Pineal gland
Human brain: Subcommissural organ
Human brain: Area postrema

Circumventricular organs (CVOs) (circum-: around ; ventricular: of ventricle) are structures in the brain characterized by their extensive and highly permeable capillaries, unlike those in the rest of the brain where there exists a blood–brain barrier (BBB) at the capillary level.[1][2][3][4] Although the term "circumventricular organs" was originally proposed in 1958 by Austrian anatomist Helmut O. Hofer concerning structures around the brain ventricular system,[5] the penetration of blood-borne dyes into small specific CVO regions was discovered in the early 20th century.[6] The permeable CVOs enabling rapid neurohumoral exchange include the subfornical organ (SFO), the area postrema (AP), the vascular organ of lamina terminalis (VOLT — also known as the organum vasculosum of the lamina terminalis (OVLT)), the median eminence, the pituitary neural lobe, and the pineal gland.[1][7]

The circumventricular organs are midline structures around the third and fourth ventricles that are in contact with blood and cerebrospinal fluid, and they facilitate special types of communication between the central nervous system and peripheral blood.[1][8][9] Additionally, they are an integral part of neuroendocrine function.[10][11] Highly permeable capillaries allow the CVOs to act as an alternative route for peptides and hormones in the neural tissue to sample from and secrete to circulating blood.[1][12][13] CVOs also have roles in body fluid regulation, cardiovascular functions, immune responses, thirst, feeding behavior and reproductive behavior.[1][7]

CVOs can be classified as either sensory or secretory organs serving homeostatic functions and body water balance.[3][7] The sensory organs include the area postrema, the subfornical organ, and the vascular organ of lamina terminalis, all having the ability to sense signals in blood, then pass that information neurally to other brain regions. Through their neural circuitry, they provide direct information to the autonomic nervous system from the systemic circulation.[1][10][14][15] The secretory organs include the subcommissural organ (SCO), the pituitary gland, the median eminence, and the pineal gland.[7][11] These organs are responsible for secreting hormones and glycoproteins into the peripheral blood using feedback from both the brain environment and external stimuli.[7]

Circumventricular organs contain capillary networks that vary between one another and within individual organs both in density and permeability, with most CVO capillaries having a permeable endothelial cell layer, except for those in the subcommissural organ.[1][16] Furthermore, all CVOs contain neural tissue, enabling a neuroendocrine role.

Although the choroid plexus also has permeable capillaries, it does not contain neural tissue; rather, its primary role is to produce cerebrospinal fluid (CSF), and therefore is typically not classified as a CVO.[1]

Sensory organs

Area postrema

Anatomy

The area postrema is located in the caudal medulla oblongata near the junction of the brainstem and the spinal cord.[16] In humans and in most other mammals that have been studied, it consists of swellings on either wall of the fourth ventricle.[16][17] In rodents and lagomorphs, however, the area postrema forms a midline structure dorsal to the obex.[18][16] When viewed histologically for its capillary distribution and morphology, the area postrema has numerous subregions separated according to capillary permeability, rates of blood flow, and duration of blood transit through respective capillary beds.[2]

Function

Relatively little is known about the function of the area postrema in humans. However, there is strong evidence that the area postrema acts as the chemoreceptor trigger zone for vomiting,[19] which is triggered by the presence of noxious stimulation from the blood.[17] There is also evidence that the area postrema is the site at which angiotensin stimulates glucose metabolism, presumed efferent neural activity, blood pressure control, and thirst.[20][21] The area postrema also has integrative capacities that enable it to send major and minor efferents to sections of the brain involved in the autonomic control of cardiovascular and respiratory activities.[17][21]

Vascular organ of the lamina terminalis

Anatomy

Classified as a sensory circumventricular organ (along with the SFO and AP),[13] the vascular organ of lamina terminalis (VOLT) is situated in the anterior wall of the third ventricle.[22] Characteristically of the CVOs, it lacks the tight endothelial blood brain barrier.[22][23] The vascular organ is further characterized by the afferent inputs from the subfornical organ (SFO), the median pre-optic nucleus (MnPO) region, the brainstem, and even the hypothalamus. Conversely, the vascular organ of the lamina terminalis maintains efferent projections to the stria medullaris and basal ganglia.[14]

As a major player in the maintenance of the mammalian body fluid homeostasis, the VOLT features the primary neurons responsible for osmosensory balance.[23][24] These neurons, in turn, feature angiotensin type I receptors, which are used by circulating angiotensin II to initiate water intake and sodium consumption.[13] In addition to the angiotensin receptors, the neurons of the VOLT are also characterized by the presence of a nonselective cation channel deemed the transient receptor potential vanilloid 1, or TRPV1.[23][24] Though there are other receptors within the TRPV family, a study by Ciura, Liedtke, and Bourque demonstrated that hypertonicity sensing operated via a mechanical mechanism of TRPV1 but not TRPV4.[23] Despite a significant amount of data, the anatomy of the VOLT is not yet fully comprehended.

Function

As previously mentioned, the vascular organ of lamina terminalis features neurons responsible for the homeostatic conservation of osmolarity.[24] In addition, the fenestrated vasculature of the VOLT allows the astrocytes and neurons of the VOLT to perceive a wide variety of plasma molecules whose signals may be transduced into other regions of the brain, thereby eliciting autonomic and inflammatory reactions.[13]

In experiments, mammalian VOLT neurons were shown to transduce hypertonicity by the activation of the TRPV1 nonselective cation channels. These channels are highly permeable to calcium and are responsible for membrane depolarization and increased action potential discharge.[23] Stated simply, an increase in osmolarity results in a reversible depolarization of the VOLT neurons.[14] This can be seen through the predominantly excitatory effects of ANG on the VOLT through the TRPV1 receptor. In this context, it is worthy to note the VOLT neurons typically feature a resting membrane potential in the range of -50 to -67 mV with input resistances ranging from 65 to 360 MΩ.[14]

Despite a solid understanding of the VOLT’s role in the maintenance of body fluid homeostasis, other functions are less understood. For example, it is thought that the VOLT may also play a role in the regulation of LH secretion via a negative feedback mechanism.[14] It is also hypothesized that the VOLT may be the mechanism through which pyrogens function to initiate a febrile response in the CNS.[14] Finally, VOLT neurons have been observed to respond to temperature changes indicating that the organum vasculosum of the lamina terminalis is subject to different climates.[14]

Subfornical organ (SFO)

Anatomy

The subfornical organ is a sensory CVO situated on the underside of the fornix and lacking a BBB, the absence of which characterizes the circumventricular organs. Protruding into the third ventricle of the brain, the highly vascularized SFO can be divided into 3–4 anatomical zones, especially by its capillary density and structure.[25][26] The central zone is composed exclusively of the glial cells and neuronal cell bodies. Conversely, the rostral and caudal areas are mostly made of nerve fibers while very few neurons and glial cells can be seen in this area.[14] Functionally, however, the SFO may be viewed in two portions, the dorsolateral peripheral (pSFO) division and the ventromedial core segment.[25][27]

As an important mechanism of both energy and osmotic homeostasis, the SFO has many efferent projections. In fact, SFO neurons have been experimentally shown to broadcast efferent projections to regions involved in cardiovascular regulation including the lateral hypothalamus with fibers terminating in the supraoptic (SON) and paraventricular (PVN) nuclei, and the anteroventral 3rd ventricle (AV3V) with fibers terminating in the VOLT and the median preoptic area.[14][28][29] It seems that the most essential of all these connections is the SFO’s projections to the paraventricular hypothalamic nucleus.[27] Based on their functional relevance, the SFO neurons can be branded as either GE, featuring nonselective cation channels, or GI, featuring potassium channels.[28] While the afferent projections of the SFO are considered less important than the various efferent connections, it is still notable that the subfornical organ receives synaptic input from the zona incerta and arcuate nucleus.[30]

Study of subfornical organ anatomy is still ongoing but evidence has demonstrated slow blood transit time which may facilitate the sensory capability of SFO, enabling increased contact time for blood-borne signals to penetrate its permeable capillaries and influence regulation of blood pressure and body fluids.[26] This observation coincides with the fact that SFO neurons have been shown to be intrinsically osmosensitive.[14] Finally, it has been established that SFO neurons maintain resting membrane potential in the range of -57 to -65 mV.[14]

Function

The subfornical organ is active in many bodily processes including, but not limited to, osmoregulation,[27][30] cardiovascular regulation,[27][29] and energy homeostasis.[29] In a study by Ferguson, both hyper- and hypotonic stimuli facilitated an osmotic response.[14] This observation demonstrated the fact that the SFO is involved in the maintenance of blood pressure. Featuring an AT1 receptor for ANG, the SFO neurons demonstrate an excitatory response when activated by ANG, therefore increasing blood pressure.[14] The induction of the drinking response via the SFO can be antagonized, however, by the peptide, ANP.[14] Additional research has demonstrated that the subfornical organ may be an important intermediary though which leptin acts to maintain blood pressure within normal physiological limits via descending autonomic pathways associated with cardiovascular control.[29]

Recent research has focused on the subfornical organ as an area particularly important in the regulation of energy. The observation that subfornical neurons respond to a wide range of circulating energy balance signals, and that electrical stimulation of the SFO in rats resulted in food intake supports the SFO’s importance in energy homeostasis.[28] Additionally, it is assumed that the SFO is the lone forebrain structure capable of constant monitoring of circulating concentrations of glucose.[28] This responsiveness to glucose again serves to solidify the SFO’s integral role as a regulator of energy homeostasis.[28]

Secretory organs

Subcommissural organ

Anatomy

The subcommissural organ (SCO) is a small secretory organ located on the ventral surface of the posterior commissure near the anterior entrance of the cerebral aqueduct.[1][31] It differs from other CVOs in that it does not have highly permeable capillaries.[1] Its role as a neuroendocrine structure associated with the ventricular system qualifies it for classification as a CVO.[1] Related to its secretory function, the SCO is partially composed of ependymal cells.[1][31] These ependymocytes are characterized by elongated cell bodies that contain secretory materials and are covered in cilia.[1][31] The most prominent of these is the glycoprotein SCO-spondin.[32]

Function

One function of the SCO is the secretion of the glycoprotein SCO-spondin, which is released into the third ventricle where it aggregates to create Reissner's fiber.[33] Reissner's fiber is a long fibrous projection that travels caudally through the Sylvian aqueduct and terminates in the spinal cord.[1][31] This fiber is thought to contribute to the maintenance of the patency of the Sylvian aqueduct.[31]

While the function of the subcommissural organ remains under investigation,[1] it may be part of the mechanism of aldosterone secretion and CSF detoxification, along with osmoregulation.[33] The SCO is innervated by many systems, the most common of which is associated with the serotonergic system, which influences water and sodium intake. During water deprivation, it will also reduce its innervation to the SCO. The reduction of input to the SCO causes a marked decrease in RF production. This finding implies that the subcommissural organ and its associated Reissner's fiber are integral parts of fluid electrolyte balance and water homeostasis.[33]

Pituitary neural lobe

The pituitary gland is subdivided into lobes – the anterior pituitary, the intermediate pituitary, and the posterior pituitary (also known as the adenohypophysis and neurohypophysis (or neural lobe), respectively).[1][34] Each one functions as a separate endocrine organ.

The pituitary neural lobe consists of axonal projections that directly extend from cell bodies in the hypothalamus through the infundibulum.[34] Under neurohumoral control, it secretes oxytocin and vasopressin, thereby qualifying it as a circumventricular organ with both neural and secretory functions.[1]

The anterior pituitary contains non-neural secretory cells derived from oral ectoderm which are indirectly controlled by "releasing hormones" from the median eminence of the hypothalamus, through the hypophyseal portal circulation.

The intermediate lobe (also called pars intermedia) synthesizes and secretes a hormone stimulating melanocytes under neural control by the hypothalamus.[35] It is not commonly included among circumventricular organs.[1]

The pituitary gland is located in the sella turcica of the sphenoid bone at the base of the skull.[36]

Median eminence

The median eminence (ME) is located in the inferior portion of the hypothalamus and is ventral to the third ventricle. While some publications do not list the ME as a CVO, when it is considered to be a circumventricular organ, it is classified as a secretory organ. The median eminence is rich in fenestrated capillaries, allowing for the passage of proteins and neurohormones. More specifically, the median eminence allows for the transport of neurohormones between the CSF and the peripheral blood supply.[37] The major cell type that makes up the median eminence are specialized ependymal cells known as tanycytes. These contribute to the organ's ability to selectively allow macromolecules to pass from the central to the peripheral neuroendocrine systems.[12][37] Ventromedial subregions of the bilateral hypothalamic arcuate nucleus display relatively high capillary permeability, indicating this nucleus may have moment-to-moment regulatory roles for sensing and neurally conveying hormonal signals.[38]

Tanycytes line the floor of the third ventricle and can be characterized by a singular long projection that delves deep inside the hypothalamus. Tanycytes have been evolutionarily linked to radial glial cells of the central nervous system. The tanycytes of the median eminence are often found along the fenestrated peripheral capillaries. They are tightly packed on the capillaries, forming a seal between the third ventricle and the median eminence. This seal can be attributed to the tight junctions observed between tanycytes and functions to restrict the travel of molecules between the median eminence and the third ventricle.[12] The median eminence is also closely linked to the transport of GnRH between the median eminence and the anterior pituitary. Neuronal projections of GnRH neurons actually end at the median eminence, allowing for its release into the portal blood system.[39][40]

Pineal gland

Anatomy

Gross anatomy

The morphology of the pineal gland varies greatly among mammals. The most commonly used classification for this gland takes into account its location relative to the diencephalon and the third ventricle of the brain, as well as its size and shape.[41] Under these conditions, the human pineal gland is classified as type A.[41] A type A pineal gland rests proximally to the posterior section of the diencephalon. It is located within 1-2mm of the midline of the brain.[41] The pineal gland starts to develop during the second month of gestation. In the average adult, the dimensions are as follow: 5-9mm in length, 1-5mm in width and 3-5mm in thickness. Its average weight is 100–180 mg.[41] The pineal gland consists of a central core made up of small lobes and a cortex that possesses a diffuse distribution of neurons. The principal cell type of the pineal is the pinealocyte sensu stricto. This type of cell has a prominent nucleus and a granular appearance.[41]

Vascularization and innervation

The level of vascularization in the pineal gland is high.[42] It receives a large supply of blood from branches of the posterior choroidal arteries that derive from cerebral arteries in the posterior mesencephalon.[41][42]

The pineal gland is innervated by fibers from the peripheral parasympathetic and sympathetic systems, in addition to fibers from the central nervous system.[43] The most important set of fibers involved are the unmyelinated postganglionic sympathetic fibers from the superior cervical ganglia, which also form the bilateral nervi conarii.[41] The second set of fibers enters the pineal gland anteriorly via the commissural peduncles.[41] The third set of fibers is myelinated and forms the ventro-lateral pineal tract.[41]

Function

The pineal gland is considered a secretory organ and its activity shows circadian oscillations.[43] Its main function – secretion of the hormone melatonin – rests when there is no input from the primary circadian pacemaker in the suprachiasmatic nuclei.[41] Melatonin production is controlled by the previously mentioned circadian timing and is suppressed by light.[41] Pineal tumors can affect sexual development,[41] but the mechanism has yet to be established.

Other pineal substances

Other peptides aside from melatonin have been detected in the pineal. They are most likely associated with a type of innervation deemed "pineal peptidergic innervation."[41] These include vasopressin, oxytocin, VIP, NPY, peptide histidine isoleucine, calcitonin gene-related peptide, substance P and somatostatin.[41]

References

  1. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Gross PM, Weindl A (1987). "Peering through the windows of the brain (Review)". Journal of Cerebral Blood Flow and Metabolism. 7 (6): 663–72. doi:10.1038/jcbfm.1987.120. PMID 2891718.
  2. 1 2 Gross, P. M (1992). Circumventricular organ capillaries. Progress in Brain Research. Vol. 91. pp. 219–33. doi:10.1016/S0079-6123(08)62338-9. ISBN 9780444814197. PMID 1410407.
  3. 1 2 Fry, W.M.; Ferguson, A.V. (2009). "Circumventricular Organs". Encyclopedia of Neuroscience. Elsevier. pp. 997–1002. doi:10.1016/b978-008045046-9.00462-9. ISBN 978-0-08-045046-9. Neurons in the sensory CVOs are ideally positioned at the blood–brain interface to monitor major constituents of body fluids.
  4. ↑ Kaur, C; Ling, EA (September 2017). "The circumventricular organs". Histology and Histopathology. 32 (9): 879–892. doi:10.14670/HH-11-881. PMID 28177105.
  5. ↑ Hofer H (1958). "Zur Morphologie der circumventriculären Organe des Zwischenhirns der Säugetiere". Verhandlungen der Deutschen Zoologischen Gesellschaft. 55: 202–251.
  6. ↑ Wislocki, George B.; King, Lester S. (1936). "The permeability of the hypophysis and hypothalamus to vital dyes, with a study of the hypophyseal vascular supply". American Journal of Anatomy. 58 (2): 421–472. doi:10.1002/aja.1000580206. ISSN 0002-9106.
  7. 1 2 3 4 5 Gross PM, ed. (1987). Circumventricular Organs and Body Fluids, Volumes I-III. CRC Press, Inc. p. 688. ISBN 978-0849367984.
  8. ↑ Johnson, AK; Gross, PM (May 1993). "Sensory circumventricular organs and brain homeostatic pathways". FASEB Journal. 7 (8): 678–86. doi:10.1096/fasebj.7.8.8500693. PMID 8500693. S2CID 13339562.
  9. ↑ Sisó, S; Jeffrey, M; González, L (December 2010). "Sensory circumventricular organs in health and disease". Acta Neuropathologica. 120 (6): 689–705. doi:10.1007/s00401-010-0743-5. PMID 20830478. S2CID 33549996.
  10. 1 2 Fry M, Ferguson AV (2007). "The sensory circumventricular organs: Brain targets for circulating signals controlling ingestive behavior". Physiology & Behavior. 91 (4): 413–423. doi:10.1016/j.physbeh.2007.04.003. PMID 17531276. S2CID 28981416.
  11. 1 2 Cottrell G. T.; Ferguson A. V. (2004). "Sensory circumventricular organs: Central roles in integrated autonomic regulation". Regulatory Peptides. 117 (1): 11–23. doi:10.1016/j.regpep.2003.09.004. PMID 14687696. S2CID 32634974.
  12. 1 2 3 Rodríguez Esteban M.; Blázquez Juan L.; Guerra Montserrat (2010). "The design of barriers in the hypothalamus allows the median eminence and the arcuate nucleus to enjoy private milieus: The former opens to the portal blood and the latter to the cerebrospinal fluid". Peptides. 31 (4): 757–76. doi:10.1016/j.peptides.2010.01.003. PMID 20093161. S2CID 44760261.
  13. 1 2 3 4 Morita S.; Miyata S. (2012). "Different vascular permeability between the sensory and secretory circumventricular organs of adult mouse brain". Cell and Tissue Research. 349 (2): 589–603. doi:10.1007/s00441-012-1421-9. PMID 22584508. S2CID 15228158.
  14. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Ferguson A. V.; Bains J. S. (1996). "Electrophysiology of the circumventricular organs". Frontiers in Neuroendocrinology. 17 (4): 440–475. doi:10.1006/frne.1996.0012. PMID 8905349. S2CID 27242916.
  15. ↑ Zimmerman, CA; Leib, DE; Knight, ZA (August 2017). "Neural circuits underlying thirst and fluid homeostasis". Nature Reviews. Neuroscience. 18 (8): 459–469. doi:10.1038/nrn.2017.71. PMC 5955721. PMID 28638120.
  16. 1 2 3 4 Duvernoy HM, Risold P-Y (2007). "The circumventricular organs: An atlas of comparative anatomy and vascularization". Brain Research Reviews. 56 (1): 119–147. doi:10.1016/j.brainresrev.2007.06.002. PMID 17659349. S2CID 43484965.
  17. 1 2 3 Lavezzi A. M.; Mecchia D.; Matturri L. (2012). "Neuropathology of the Area Postrema in Sudden Intrauterine and Infant Death Syndromes Related to Tobacco Smoke Exposure". Autonomic Neuroscience: Basic and Clinical. 166 (1–2): 29–34. doi:10.1016/j.autneu.2011.09.001. PMID 21982783. S2CID 10455802.
  18. ↑ Brizzee KR, Klara PM (1984). "The structure of the mammalian area postrema". Federation Proceedings. 43 (15): 2944–2948. PMID 6500067.
  19. ↑ Borison H. L. (1989). "Area Postrema: Chemoreceptor Circumventricular Organ of the Medulla Oblongata". Progress in Neurobiology. 32 (5): 351–90. doi:10.1016/0301-0082(89)90028-2. PMID 2660187. S2CID 34914186.
  20. ↑ Shaver, S. W; Kadekaro, M; Gross, P. M (1989). "High metabolic activity in the dorsal vagal complex of Brattleboro rats". Brain Research. 505 (2): 316–20. doi:10.1016/0006-8993(89)91459-5. PMID 2598049. S2CID 32921413.
  21. 1 2 Gross, P. M; Wainman, D. S; Shaver, S. W; Wall, K. M; Ferguson, A. V (1990). "Metabolic activation of efferent pathways from the rat area postrema". American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 258 (3 Pt 2): R788–97. doi:10.1152/ajpregu.1990.258.3.R788. PMID 2316724.
  22. 1 2 Ott D.; Murgott J.; Rafalzik S.; Wuchert F.; Schmalenbeck B.; Roth J.; Gerstberger R. (2010). "Neurons and glial cells of the rat organum vasculosum laminae terminalis directly respond to lipopolysaccharide and pyrogenic cytokines". Brain Res. 1363: 93–106. doi:10.1016/j.brainres.2010.09.083. PMID 20883673. S2CID 22807384.
  23. 1 2 3 4 5 Ciura Sorana; Liedtke Wolfgang; Borque Charles (2011). "Hypertonicity Sensing in Organum Vasculosum Lamina Terminalis Neurons: A Mechanical Process Involving TRPV1 But Not TRPV4". The Journal of Neuroscience. 31 (41): 14669–14676. doi:10.1523/JNEUROSCI.1420-11.2011. PMC 6703397. PMID 21994383.
  24. 1 2 3 Issa A.T.; Miyata K.; Heng V.; Mitchell K.D.; Derbenev A.V. (2012). "Increased neuronal activity in the OVLT of Cyp1a1-Ren2 transgenic rats with inducible Ang II-dependent malignant hypertension". Neurosci. Lett. 519 (1): 26–30. doi:10.1016/j.neulet.2012.05.006. PMID 22579820. S2CID 46410313.
  25. 1 2 Sposito, N. M; Gross, P. M (1987). "Topography and morphometry of capillaries in the rat subfornical organ". The Journal of Comparative Neurology. 260 (1): 36–46. doi:10.1002/cne.902600104. PMID 3597833. S2CID 26102264.
  26. 1 2 Gross, P. M (1991). "Morphology and physiology of capillary systems in subregions of the subfornical organ and area postrema". Canadian Journal of Physiology and Pharmacology. 69 (7): 1010–25. doi:10.1139/y91-152. PMID 1954559.
  27. 1 2 3 4 Kawano H.; Masuko S. (2010). "Region-specific projections from the subfornical organ to the paraventricular hypothalamic nucleus in the rat". Neuroscience. 169 (3): 1227–1234. doi:10.1016/j.neuroscience.2010.05.065. PMID 20678996. S2CID 29552630.
  28. 1 2 3 4 5 Medeiros N.; Dai L.; Ferguson A.V. (2012). "Glucose-responsive neurons in the subfornical organ of the rat—a novel site for direct CNS monitoring of circulating glucose". Neuroscience. 201: 157–165. doi:10.1016/j.neuroscience.2011.11.028. PMID 22108616. S2CID 42666437.
  29. 1 2 3 4 Smith P. M.; Ferguson A. V. (2012). "Cardiovascular Actions of Leptin in the Subfornical Organ are Abolished by Diet-Induced Obesity". Journal of Neuroendocrinology. 24 (3): 504–510. doi:10.1111/j.1365-2826.2011.02257.x. PMID 22103447. S2CID 25751631.
  30. 1 2 Miyahara N.; Ono K.; Hitomi S.; Hirase M.; Inenaga K. (2012). "Dopamine modulates neuronal excitability pre- and post-synaptically in the rat subfornical organ". Brain Res. 1447: 44–52. doi:10.1016/j.brainres.2012.01.063. PMID 22356889. S2CID 24176208.
  31. 1 2 3 4 5 Rodríguez, Esteban M.; Rodríguez, Sara; Hein, Silvia (1998-04-15). "The subcommissural organ". Microscopy Research and Technique. 41 (2): 98–123. doi:10.1002/(sici)1097-0029(19980415)41:2<98::aid-jemt2>3.0.co;2-m. ISSN 1059-910X. PMID 9579598. S2CID 358861.
  32. ↑ Saha S.; Subhedar N. (2011). "Calcitonin-like immunoreactivity in the subcommissural organ–Reissner's fiber complex of some freshwater and marine teleosts". Journal of Chemical Neuroanatomy. 41 (2): 122–128. doi:10.1016/j.jchemneu.2010.12.004. PMID 21184824. S2CID 31479100.
  33. 1 2 3 Elgot A.; Ahboucha S.; Bouyatas M. M.; Fèvre-Montange M.; Gamrani H. (2009). "Water deprivation affects the serotoninergic system and glycoprotein secretion in the sub-commissural organ of a desert rodent Meriones shawi". Neuroscience Letters. 466 (1): 6–10. doi:10.1016/j.neulet.2009.08.058. PMID 19716402. S2CID 20941735.
  34. 1 2 Marieb, Elaine N. Human Anatomy and Physiology. 6th ed. N.p.: Benjamin Cummings, 2003. Print.
  35. ↑ Lamacz, M.; Tonon, M. C.; Louiset, E.; Cazin, L.; Vaudry, H. (1991). "Le lobe intermédiaire de l'hypophyse, modèle de communication neuroendocrinienne (abstract in English)". Archives Internationales de Physiologie, de Biochimie et de Biophysique. 99 (3): 205–219. doi:10.3109/13813459109146925. ISSN 0778-3124. PMID 1717055.
  36. ↑ Amar A. P.; Weiss M. H. (2003). "Pituitary Anatomy and Physiology". Neurosurgery Clinics of North America. 14 (1): 11–23. doi:10.1016/S1042-3680(02)00017-7. PMID 12690976.
  37. 1 2 Mullier A.; Bouret S. G.; Prevot V.; Dehouck B. (2010). "Differential distribution of tight junction proteins suggests a role for tanycytes in blood-hypothalamus barrier regulation in the adult mouse brain". J. Comp. Neurol. 518 (7): 943–962. doi:10.1002/cne.22273. PMC 2892518. PMID 20127760.
  38. ↑ Shaver, SW; Pang, JJ; Wainman, DS; Wall, KM; Gross, PM (1992). "Morphology and function of capillary networks in subregions of the rat tuber cinereum". Cell and Tissue Research. 267 (3): 437–48. doi:10.1007/BF00319366. PMID 1571958. S2CID 27789146.
  39. ↑ Yin W.; Mendenhall J. M.; Monita M.; Gore A. C. (2009). "Three-dimensional properties of GnRH neuroterminals in the median eminence of young and old rats". J. Comp. Neurol. 517 (3): 284–295. doi:10.1002/cne.22156. PMC 2821827. PMID 19757493.
  40. ↑ Uenoyama Y.; Inoue N.; Pheng V.; Homma T.; Takase K.; Yamada S.; Ajiki K.; Ichikawa M.; Okamura H.; Maeda K.-I.; Tsukamura H. (2011). "Ultrastructural Evidence of Kisspeptin-Gonadotrophin-Releasing Hormone (GnRH) Interaction in the Median Eminence of Female Rats: Implication of Axo-Axonal Regulation of GnRH Release". Journal of Neuroendocrinology. 23 (10): 863–870. doi:10.1111/j.1365-2826.2011.02199.x. PMID 21815953. S2CID 2721782.
  41. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Bruce J. N. (2004). "Human Pineal Physiology and Functional Significance of Melatonin". Frontiers in Neuroendocrinology. 25 (3–4): 177–95. doi:10.1016/j.yfrne.2004.08.001. PMID 15589268. S2CID 26142713.
  42. 1 2 Murakami, Takuro; Kikuta, Akio; Taguchi, Takehito; Ohtsuka, Aiji (1988). "The blood vascular architecture of the rat pineal gland: A scanning electron microscopic study of corrosion casts". Archives of Histology and Cytology. 51 (1): 61–69. doi:10.1679/aohc.51.61. ISSN 0914-9465. PMID 3137949.
  43. 1 2 Reiter, Russel J. (1981). "The mammalian pineal gland: Structure and function (Review)". American Journal of Anatomy. 162 (4): 287–313. doi:10.1002/aja.1001620402. ISSN 0002-9106. PMID 7325124.
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