5-methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase
Identifiers
EC no.2.1.1.258
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

5-methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase (EC 2.1.1.258, acsE (gene)) is an enzyme with systematic name 5-methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction

[Methyl-Co(III) corrinoid Fe-S protein] + tetrahydrofolate a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrofolate

This enzyme catalyses the transfer of a methyl group from the N5 position of methyltetrahydrofolate to the 5-methoxybenzimidazolylcobamide cofactor of a corrinoid/Fe-S protein, containing a corrin ring similar to that in cobalamin.

References

  1. Roberts DL, Zhao S, Doukov T, Ragsdale SW (October 1994). "The reductive acetyl coenzyme A pathway: sequence and heterologous expression of active methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase from Clostridium thermoaceticum". Journal of Bacteriology. 176 (19): 6127–30. doi:10.1128/jb.176.19.6127-6130.1994. PMC 196833. PMID 7928975.
  2. Doukov T, Seravalli J, Stezowski JJ, Ragsdale SW (August 2000). "Crystal structure of a methyltetrahydrofolate- and corrinoid-dependent methyltransferase". Structure. 8 (8): 817–30. doi:10.1016/s0969-2126(00)00172-6. PMID 10997901.
  3. Doukov TI, Hemmi H, Drennan CL, Ragsdale SW (March 2007). "Structural and kinetic evidence for an extended hydrogen-bonding network in catalysis of methyl group transfer. Role of an active site asparagine residue in activation of methyl transfer by methyltransferases". The Journal of Biological Chemistry. 282 (9): 6609–6618. doi:10.1074/jbc.m609828200. PMC 3966722. PMID 17172470.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.