David Burke may refer to:

Entertainment

• David Burke (British actor) (born 1934), British television actor
• David Burke (American actor) (born 1967), American television actor
• David Burke (author), language books author
• David J. Burke (born 1948), producer, screenwriter and film and television director
• David Burke, author of a book on Melita Norwood
• David "Bombhead" Burke, a character played by Lee Otway on Hollyoaks
• D4vd, American singer and songwriter

Sports

• David Burke (Australian footballer) (born 1959), Australian rules footballer
• David Burke (English footballer) (born 1960), English footballer
• David Burke (boxer) (born 1975), English boxer
• David Burke (Galway hurler) (born 1990), Irish hurler for Galway
• David Burke (Kilkenny hurler) (born 1981), Irish hurler for Kilkenny and Wexford
• David Burke (athlete) in 1986 IAAF World Cross Country Championships – Junior men's race
• David Burke (soccer), played for Albany BWP Highlanders
• Davy Burke, Irish Gaelic football manager and former player

Others

• David Burke (politician) (born 1967), member of the Ohio House of Representatives
• David Burke (botanist) (1854–1897), English botanist
• David Burke (chef) (born 1962), chef and restaurateur
• David W. Burke (1935–2014), American television news executive
• David A. Burke (1952–1987), American hijacker and former employee who caused the crash of Pacific Southwest Airlines Flight 1771
• David Burke (neurophysiologist) (born circa 1944), Australian expert in spinal and brain trauma