David Knox may refer to:
- David Knox (photographer) (1821–1895), Scottish-American photographer of the American Civil War
- David Broughton Knox (1916–1994), Australian Anglican priest, Principal of Moore Theological College, 1959–1985
- Sir David Knox (politician) (born 1933), English Conservative Member of Parliament
- David Knox (rugby union) (born 1963), Australian rugby union player and coach
- David Knox (businessman) (fl. 2003–), Scottish/Australian businessman and director of oil and gas company Santos
- David Knox (rugby league) (fl. 1964–1971), Australian rugby league player
- David Knox (fl. 2007–), creator of Australian-based website TV Tonight
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