De Backer may refer to:

  • Augustin de Backer (1809–1873), Belgian Jesuit and bibliographer
  • Bert De Backer (born 1984), Belgian cyclist
  • Jacob de Backer (c. 1555–c. 1591), Flemish Mannerist painter and draughtsman active in Antwerp
  • Gotye (born Wouter De Backer in 1980), Australian singer-songwriter
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