CAF Confederation Cup

Winning the 2009–10 Ethiopian Cup meant Dedebit had qualified for the preliminary round of the 2011 CAF Confederation Cup. In the 2010-11 season, Dedebit were drawn against Tanzania's Young Africans in the preliminary round of the CAF Confederation. The first leg, held in Dar-es-selam, was a high scoring affair with the match ending in a 4–4 draw. The most significant aspect of this match was that it was Dedebit's very first competitive continental and international match. Having already collected 4 away goals, Dedebit had an outstanding second leg cruising to a 2–0 win at home, advancing into the first round 6–4 on aggregate. In the first round of the competition, Dedebit were matched up against Egyptian side Haras El Hodoud SC. The first leg saw Dedebit get thrashed 4–0 in Alexandria, suffering their first defeat of the competition. On the return leg in Addis Ababa, they were only able to earn a 1–1 draw (finishing 1–5 on aggregate), in the process being eliminated from the competition.

Dedebit qualified for the 2013 CAF Confederation Cup, but unfortunately they met the same fate as two years prior, being eliminated in the first round of the competition.

CAF Champions League

By virtue of winning the 2012–13 Ethiopian Premier League, Dedebit qualified for the preliminary round of the 2014 CAF Champions League. Drawn against KMKM of Zanzibar in the preliminary round, the first leg in Addis Ababa saw Dedebit easily handle their opponents cruising to a 3–0 win. The second leg was a different story as KMKM were dominant on the day winning 2–0, but falling short of leveling the fixture on aggregate as Dedebit were able to advance to the next round. In the first round, Dedebit met CS Sfaxien of Tunisia with the first leg held in Addis Ababa, where Dedebit fell 2–1. The return leg in Tunis saw CS Sfaxien walking away victorious 2–0, advancing 4–1 on aggregate and eliminating Dedebit in the process.^[4]