ELAVL3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesELAVL3, HUC, HUCL, PLE21, ELAV like neuron-specific RNA binding protein 3, ELAV like RNA binding protein 3
External IDsOMIM: 603458 MGI: 109157 HomoloGene: 31035 GeneCards: ELAVL3
Orthologs
SpeciesHumanMouse
Entrez

1995

15571

Ensembl

ENSG00000196361

ENSMUSG00000003410

UniProt

Q14576

Q60900

RefSeq (mRNA)

NM_001420
NM_032281

NM_010487

RefSeq (protein)

NP_001411
NP_115657

NP_034617

Location (UCSC)Chr 19: 11.45 – 11.48 MbChr 9: 21.93 – 21.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ELAV-like protein 3 is a protein that in humans is encoded by the ELAVL3 gene.[5][6]

A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000196361 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003410 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Van Tine BA, Knops JF, Butler A, Deloukas P, Shaw GM, King PH (Dec 1998). "Localization of HuC (ELAVL3) to chromosome 19p13.2 by fluorescence in situ hybridization utilizing a novel tyramide labeling technique". Genomics. 53 (3): 296–9. doi:10.1006/geno.1998.5468. PMID 9799595.
  6. 1 2 "Entrez Gene: ELAVL3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)".

Further reading


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