EPFL refers to the École polytechnique fédérale de Lausanne, a research institute in Switzerland.
EPFL may also refer to:
- Rolex Learning Center, also known as the EPFL Learning Center, a campus and library in Switzerland
- Presses polytechniques et universitaires romandes, a Swiss publishing house, the English imprint is known as EPFL Press
- Eastern Pennsylvania Football League, an American football league that existed in 1938
- European Leagues, an Association football organization previously known as the European Professional Football Leagues (EPFL)
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