Enrile is the surname of:
- Arturo Enrile (1940–1998), Filipino politician, cousin of Juan
- Jack Enrile (born 1958), Filipino politician, son of Juan
- Joaquín Ezpeleta Enrile (1788–?), Spanish politician and army general
- Juan Ponce Enrile (born 1924), Filipino politician and lawyer
- Pasqual Enrile y Alcedo (1772–1836), Spanish governor-general of the Philippines
- Ronjay Enrile (born 1982), Filipino basketball player
- Sally Ponce Enrile, Filipino politician, wife of Jack
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