Esco may refer to the following people:
- Given name
- Esco Sarkkinen (1918–1998), American football player and coach
- Esco Haynes, American professional baseball player
- Esco Niblo Bowen (born 1893 – died 1959), American lawyer, judge and politician
- Sigmund Esco Jackson (born 1951), American singer and musician
- William Esco Moerner (born 1953), American physical chemist and chemical physicist awarded Nobel Prize in Chemistry in 2014
- Surname
- Lina Esco (born 1985), American actress
- Nickname
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