First State Bank may refer to any one of several state bank systems or to several specific buildings, to which First State Bank Building may also refer:

Bank systems in the United States

• First State Bank (Nebraska), a five branch bank system in Nebraska

Bank buildings in the United States (and/or bank systems)

(by state)

• First State Bank of Manlius, Manlius, Illinois, listed on the NRHP in Illinois
• First State Bank (Edna, Kansas), listed on the NRHP in Kansas
• Mitchell Building-First State Bank Building, Barbourville, Kentucky, listed on the NRHP in Kentucky
• First State Bank of LeRoy, LeRoy, Minnesota, listed on the NRHP in Minnesota
• First State Bank (St. Joseph, Minnesota), listed on the NRHP in Minnesota
• First State Bank, Dowling and Emhoff Buildings, Stevensville, Montana, listed on the NRHP in Montana
• First State Bank of Chester, Chester, Montana, listed on the NRHP in Montana
• First State Bank of Bethany, Lincoln, Nebraska, listed on the NRHP in Nebraska
• First State Bank of Buxton, Buxton, North Dakota, listed on the NRHP in North Dakota
• First State Bank of Indiahoma, Indiahoma, Oklahoma, listed on the NRHP in Oklahoma
• First State Bank of Maramec, Maramec, Oklahoma, listed on the NRHP in Oklahoma
• First State Bank (Shattuck, Oklahoma), listed on the NRHP in Oklahoma
• First State Bank of Hazel, Hazel, South Dakota, listed on the NRHP in South Dakota
• First State Bank Building (Revillo, South Dakota), listed on the NRHP in South Dakota
• First State Bank and Trust Building (Bryan, Texas), listed on the NRHP in Texas
• First State Bank of Baggs, Baggs, Wyoming, listed on the NRHP in Wyoming