Grancalcin

GCA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1F4O, 1F4Q, 1K94, 1K95
Identifiers
Aliases	GCA, GCL, grancalcin
External IDs	OMIM: 607030 MGI: 1918521 HomoloGene: 22702 GeneCards: GCA
Gene location (Human)
Chr.	Chromosome 2 (human)
End	162,371,595 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	62,524,453 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; bone marrow; ; bone marrow cells; ; spongy bone; ; spleen; ; germinal epithelium; ; right lung; ; periodontal fiber; ; corpus callosum;
	Top expressed in
	morula; ; pineal gland; ; primary motor cortex; ; olfactory epithelium; ; seminal vesicula; ; sciatic nerve; ; retinal pigment epithelium; ; blastocyst; ; epithelium of stomach; ; myocardium of ventricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; protein homodimerization activity; metal ion binding; calcium-dependent cysteine-type endopeptidase activity; protein heterodimerization activity; calcium ion binding;
Cellular component	plasma membrane; extracellular exosome; membrane; extracellular region; cytosol; azurophil granule lumen; cytoplasm;
Biological process	membrane fusion; proteolysis; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	25801
	227960
	ENSG00000115271
	ENSMUSG00000026893
	P28676
	Q8VC88
NM_012198; NM_001330265; NM_001330266; NM_001330267; NM_001330268;
	NM_001330270; NM_001330271
	NM_145523
NP_001317194; NP_001317195; NP_001317196; NP_001317197; NP_001317199;
	NP_001317200; NP_036330
	NP_663498
	Wikidata
View/Edit Human	View/Edit Mouse

Grancalcin is a protein that in humans is encoded by the GCA gene.^[5]^[6]^[7]^[8]

This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.^[8]

Interactions

GCA (gene) has been shown to interact with SRI.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115271 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026893 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Boyhan A, Casimir CM, French JK, Teahan CG, Segal AW (Mar 1992). "Molecular cloning and characterization of grancalcin, a novel EF-hand calcium-binding protein abundant in neutrophils and monocytes". J Biol Chem. 267 (5): 2928–33. doi:10.1016/S0021-9258(19)50675-5. PMID 1737748.
↑ Teahan CG, Totty NF, Segal AW (Oct 1992). "Isolation and characterization of grancalcin, a novel 28 kDa EF-hand calcium-binding protein from human neutrophils". Biochem J. 286. ( Pt 2) (2): 549–54. doi:10.1042/bj2860549. PMC 1132932. PMID 1530588.
1 2 Hansen C, Tarabykina S, la Cour JM, Lollike K, Berchtold MW (Jun 2003). "The PEF family proteins sorcin and grancalcin interact in vivo and in vitro". FEBS Lett. 545 (2–3): 151–4. doi:10.1016/S0014-5793(03)00518-0. PMID 12804766. S2CID 42572647.
1 2 "Entrez Gene: GCA grancalcin, EF-hand calcium binding protein".

Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jia J, Borregaard N, Lollike K, Cygler M (2002). "Structure of Ca(2+)-loaded human grancalcin". Acta Crystallogr. D. 57 (Pt 12): 1843–9. doi:10.1107/S0907444901016511. PMID 11717497.
Lollike K, Johnsen AH, Durussel I, et al. (2001). "Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner". J. Biol. Chem. 276 (21): 17762–9. doi:10.1074/jbc.M100965200. PMID 11279160.
Jia J, Han Q, Borregaard N, et al. (2000). "Crystal structure of human grancalcin, a member of the penta-EF-hand protein family". J. Mol. Biol. 300 (5): 1271–81. doi:10.1006/jmbi.2000.3925. PMID 10903868.
Maki M, Narayana SV, Hitomi K (1998). "A growing family of the Ca2+-binding proteins with five EF-hand motifs". Biochem. J. 328. ( Pt 2) (Pt 2): 718–20. PMC 1218977. PMID 9441591.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000115271 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026893 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1737748-5] Boyhan A, Casimir CM, French JK, Teahan CG, Segal AW (Mar 1992). "Molecular cloning and characterization of grancalcin, a novel EF-hand calcium-binding protein abundant in neutrophils and monocytes". J Biol Chem. 267 (5): 2928–33. doi:10.1016/S0021-9258(19)50675-5. PMID 1737748.

[pmid1530588-6] Teahan CG, Totty NF, Segal AW (Oct 1992). "Isolation and characterization of grancalcin, a novel 28 kDa EF-hand calcium-binding protein from human neutrophils". Biochem J. 286. ( Pt 2) (2): 549–54. doi:10.1042/bj2860549. PMC 1132932. PMID 1530588.

[pmid12804766-7] 1 2 Hansen C, Tarabykina S, la Cour JM, Lollike K, Berchtold MW (Jun 2003). "The PEF family proteins sorcin and grancalcin interact in vivo and in vitro". FEBS Lett. 545 (2–3): 151–4. doi:10.1016/S0014-5793(03)00518-0. PMID 12804766. S2CID 42572647.

[entrez-8] 1 2 "Entrez Gene: GCA grancalcin, EF-hand calcium binding protein".

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Interactions

References

Further reading