Gamma-glutamyltransferase 7

GGT7
Identifiers
Aliases	GGT7, D20S101, GGT4, GGTL3, GGTL5, dJ18C9.2, gamma-glutamyltransferase 7
External IDs	OMIM: 612342 MGI: 1913385 HomoloGene: 70866 GeneCards: GGT7
EC number	3.4.19.13
Gene location (Human)
Chr.	Chromosome 20 (human)
End	34,872,856 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	155,518,237 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; right lobe of thyroid gland; ; Brodmann area 9; ; left lobe of thyroid gland; ; gastrocnemius muscle; ; gastric mucosa; ; body of pancreas; ; cingulate gyrus; ; hypothalamus; ; body of stomach;
	Top expressed in
	olfactory epithelium; ; superior frontal gyrus; ; cerebellar cortex; ; lateral geniculate nucleus; ; medial dorsal nucleus; ; medial geniculate nucleus; ; pontine nuclei; ; primary motor cortex; ; inferior colliculus; ; superior colliculus;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; glutathione hydrolase activity; acyltransferase activity; protein binding; hydrolase activity; hypoglycin A gamma-glutamyl transpeptidase activity; leukotriene C4 gamma-glutamyl transferase activity; peptidyltransferase activity;
Cellular component	integral component of membrane; membrane; plasma membrane;
Biological process	glutathione biosynthetic process; proteolysis; glutathione catabolic process; glutathione metabolic process; leukotriene D4 biosynthetic process; negative regulation of response to oxidative stress; protein biosynthesis; cellular amino acid metabolic process; glutamate metabolic process; cysteine biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	2686
	207182
	ENSG00000131067
	ENSMUSG00000027603
	Q9UJ14
	Q99JP7
	NM_178026; NM_001351702; NM_178025
	NM_144786; NM_001362898; NM_001362900
	NP_821158; NP_001338631; NP_821158.2
	NP_659035; NP_001349827; NP_001349829
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-glutamyltransferase 7 is an enzyme that in humans is encoded by the GGT7 gene.^[5]^[6]^[7]

Function

Gamma-glutamyltransferase is a membrane-associated protein involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene is similar in sequence to gamma-glutamyltransferase, but its function is unknown.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000131067 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027603 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Figlewicz DA, Delattre O, Guellaen G, Krizus A, Thomas G, Zucman J, Rouleau GA (August 1993). "Mapping of human gamma-glutamyl transpeptidase genes on chromosome 22 and other human autosomes". Genomics. 17 (2): 299–305. doi:10.1006/geno.1993.1325. PMID 8104871.
↑ Heisterkamp N, Groffen J, Warburton D, Sneddon TP (May 2008). "The human gamma-glutamyltransferase gene family". Human Genetics. 123 (4): 321–32. doi:10.1007/s00439-008-0487-7. PMID 18357469. S2CID 15916758.
1 2 "Entrez Gene: GGTL3 gamma-glutamyltransferase-like 3".

Jikuya H, Takano J, Kikuno R, Hirosawa M, Nagase T, Nomura N, Ohara O (February 2003). "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones". DNA Research. 10 (1): 49–57. doi:10.1093/dnares/10.1.49. PMID 12693554.
Llamazares M, Cal S, Quesada V, López-Otín C (April 2003). "Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain". The Journal of Biological Chemistry. 278 (15): 13382–9. doi:10.1074/jbc.M211900200. PMC 6066313. PMID 12562771.
He X, Di Y, Li J, Xie Y, Tang Y, Zhang F, Wei L, Zhang Y, Qin W, Huo K, Li Y, Wan D, Gu J (September 2002). "Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism". Biochemical and Biophysical Research Communications. 297 (3): 528–36. doi:10.1016/S0006-291X(02)02227-1. PMID 12270127.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000131067 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027603 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8104871-5] Figlewicz DA, Delattre O, Guellaen G, Krizus A, Thomas G, Zucman J, Rouleau GA (August 1993). "Mapping of human gamma-glutamyl transpeptidase genes on chromosome 22 and other human autosomes". Genomics. 17 (2): 299–305. doi:10.1006/geno.1993.1325. PMID 8104871.

[pmid18357469-6] Heisterkamp N, Groffen J, Warburton D, Sneddon TP (May 2008). "The human gamma-glutamyltransferase gene family". Human Genetics. 123 (4): 321–32. doi:10.1007/s00439-008-0487-7. PMID 18357469. S2CID 15916758.

[entrez-7] 1 2 "Entrez Gene: GGTL3 gamma-glutamyltransferase-like 3".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

Function

References

Further reading