GPC may refer to:
Science and medicine
- Gel permeation chromatography
- Generalized polynomial chaos
- Giant papillary conjunctivitis, a disease of the eye
- Gigaparsec, a unit of distance
- Global Plant Clinic, an agricultural organization
- Glycophorin C, a sialoglycoprotein
- Glypican, a proteoglycan
- GPC Biotech, a German biopharmaceutical company
Politics
Other uses
- Geiriadur Prifysgol Cymru, the University of Wales Dictionary of the Welsh language
- Gene Polisseni Center, a college ice hockey arena on the campus of the Rochester Institute of Technology
- General Polygon Clipper, a graphics library
- Genuine Parts Company, an American service organization
- George Pearson Centre, a long-term care facility in Vancouver, Canada
- Georgia Perimeter College in Georgia, United States
- Global Privacy Control, a data protection signal for the web
- Global Product Classification
- Global Pound Conference, a conference series on international dispute resolution
- GNU Pascal, a computer program
- Goldwyn Pictures, an American film studio that eventually merged with other studios
- Government Procurement Card, a United Kingdom government purchasing card
- Government Purchase Card, a United States government purchasing program
- GPC Sport, an auto racing team
- Putnam County Airport, in Indiana, United States
- Remington GPC, an American assault rifle
- GPC (Mystery Science Theater 3000), a robot character from Mystery Science Theater 3000
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