George Guthrie may refer to:
- George H. Guthrie (born 1959), professor at Union University
- George James Guthrie (1785–1856), English surgeon
- George W. Guthrie (1848–1917), mayor
- George Guthrie (athlete) (1904–1972), American track and field athlete
- George Guthrie (songwriter) (1842–?), Newcastle upon Tyne songwriter
See also
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