Gesine is a German feminine given name and may refer to:
- Gesine Becker (1888–1968), left wing German activist and politician
- Gesine Bullock-Prado (born 1970), American pastry chef, TV personality, author, attorney, and former film executive
- Gesine Cukrowski (born 1968), German actress
- Gesine Lötzsch (born 1961), German politician of the left-wing party Die Linke
- Gesine Manuwald, Professor of Latin and Head of the Department of Greek and Latin at University College London
- Gesine Meißner (born 1952), German politician, Member of the European Parliament (MEP) from 2009 to 2019
- Gesine Reinert, University Professor in Statistics at the University of Oxford
- Gesine Ruge, German sprint canoeist who has competed since the mid-2000s
- Gesine Schröder (born 1957), German musicologist and music theorist
- Gesine Schwan (born 1943), German political science professor, member of the Social Democratic Party of Germany
- Gesine Walther (born 1962), retired German sprinter
See also
- The Treasure of Gesine Jacobsen (German: Der Schatz der Gesine Jakobsen), a 1923 German silent drama film
- Gezin
- Gęsin
- Gęzyn
- Jessine
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