Great Debate may refer to

• The Great Debate, also called the Samye Debate, the Council of Lhasa or the Council of Samye, a decisive debate in Tibetan Buddhism from 792 to 794
• The Great Debates of 1858, the Lincoln–Douglas debates
• Great Debates (international relations), a series of disagreements between international relations scholars
• The Great Debate, a national discussion in the United Kingdom about state education, touched off by a 1976 speech by Prime Minister James Callaghan
• Great Debate (Cuba), a debate in Cuba about how to transform the economy from 1962-1965.

Science

• Great Debate (astronomy), an influential debate between the astronomers Harlow Shapley and Heber Curtis
• The Great Debate, an influential debate on the future of radiation oncology between leading Dutch professors in medical physics (2013)

Media

• The Great Debate (Canadian TV series), a Canadian television series (1974–1983)
• "The Great Debate", a song by Dream Theater from their 2002 album Six Degrees of Inner Turbulence
• The Great Debate (American TV series), a VH1 program (2009–present)
• The Great Debate (British TV series), a Sky News programme (2022–present)

Literature

• The Great Debate: Edmund Burke, Thomas Paine, and the Birth of Right and Left, a 2014 book by Yuval Levin