Great Red Dragon may refer to:
- Satan, in the Book of Revelation in the Bible
- The Great Red Dragon paintings, a series of paintings by William Blake
- Great Red Dragon, a persona of fictional character Francis Dolarhyde in Red Dragon by Thomas Harris
- Great Red Dragon, a fictional character from Bone comics
- "The Great Red Dragon" (Hannibal), an episode of the TV series
- "The Great Red Dragon", an episode of The Mentalist (season 6)
See also
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