Guevara is a surname of Basque origin. Notable people with the surname include:

• Amado Guevara (born 1976), Honduran football (soccer) player
• Álvaro Guevara (1894–1951), Chilean painter
• Ander Guevara (born 1997), Spanish footballer for Real Sociedad
• Ángel Aníbal Guevara (born 1924), Guatemalan politician
• Antonio de Guevara (c. 1481 – 1545), Spanish chronicler and moralist
• Armando Guevara (born 1955), Venezuelan boxer
• Ava Rossana Guevara, Honduran politician
• Carla Guevara (born 1975), Filipino actress
• Carlos Guevara (born March 18, 1982), US-American basketball player
• Ernesto "Che" Guevara (1928–1967), Argentine Marxist revolutionary
• Diego de Guevara (c. 1450 – 1520), Spanish diplomat and art collector
• Ena Guevara (born 1959), Peruvian long-distance runner
• Felipe de Guevara (died 1563), Spanish humanist
• Fernando Niño de Guevara (1541–1609), Spanish cardinal
• Gerardo Guevara (born 1930), Ecuadorian composer
• Giomar Guevara (born 1972), Major League Baseball shortstop who played for the Seattle Mariners
• Hermógenes Leonel Guevara Mora (born 1979), Nicaraguan poet
• Hilda Guevara, Peruvian congresswoman
• Íñigo Vélez de Guevara, Count consort of Oñate (1566–1644), Spanish diplomat and politician
• Isabel de Guevara (1530–1556), Spanish colonial chief
• Jesús Guevara (born 1969), Venezuelan heavyweight boxer
• Luis Vélez de Guevara (1579 – 1644), Spanish dramatist and novelist
• Manuel Guevara (born 1969), Venezuelan road cyclist
• Sammy Guevara (born 1993), American professional wrestler
• Otto Guevara (born 1960), Costa Rican libertarian politician
• Tomás Guevara (1865–1935), Chilean historian, teacher and Mapuche scholar