H2AC12
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesH2AC12, H2A/S, H2AFALii, H2AH, dJ86C11.1, histone cluster 1, H2ah, histone cluster 1 H2A family member h, HIST1H2AH, H2A clustered histone 12
External IDsOMIM: 615013 MGI: 2448295 HomoloGene: 119667 GeneCards: H2AC12
Orthologs
SpeciesHumanMouse
Entrez

85235

319168

Ensembl

ENSG00000274997

ENSMUSG00000069302

UniProt

Q96KK5

Q8CGP6

RefSeq (mRNA)

NM_080596

NM_175659

RefSeq (protein)

NP_542163

NP_783590

Location (UCSC)Chr 6: 27.15 – 27.15 MbChr 13: 22.22 – 22.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histone H2A type 1-H is a protein that in humans is encoded by the HIST1H2AH gene.[5][6]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000274997 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000069302 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  6. 1 2 "Entrez Gene: HIST1H2AH histone cluster 1, H2ah".

Further reading


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