H2BC14
Identifiers
AliasesH2BC14, H2B/e, H2BFE, dJ160A22.3, histone cluster 1, H2bm, histone cluster 1 H2B family member m, HIST1H2BM, H2B clustered histone 14
External IDsOMIM: 602802 MGI: 2448407 HomoloGene: 136772 GeneCards: H2BC14
Orthologs
SpeciesHumanMouse
Entrez

8342

319187

Ensembl

ENSG00000273703

ENSMUSG00000095217

UniProt

Q99879

P10853

RefSeq (mRNA)

NM_003521

NM_178201

RefSeq (protein)

NP_003512

Location (UCSC)Chr 6: 27.82 – 27.82 MbChr 13: 21.94 – 21.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histone H2B type 1-M is a protein that in humans is encoded by the HIST1H2BM gene.[5][6][7]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000273703 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000095217 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.
  6. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  7. 1 2 "Entrez Gene: HIST1H2BM histone cluster 1, H2bm".

Further reading

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