H2BC9
Identifiers
AliasesH2BC9, H2B/j, H2BFJ, histone cluster 1, H2bh, histone cluster 1 H2B family member h, HIST1H2BH, H2B clustered histone 9
External IDsOMIM: 602806 MGI: 3710645 HomoloGene: 134772 GeneCards: H2BC9
Orthologs
SpeciesHumanMouse
Entrez

8345

665622

Ensembl

ENSG00000275713

ENSMUSG00000069303

UniProt

Q93079

P10853

RefSeq (mRNA)

NM_003524

NM_001110555
NM_001313878

RefSeq (protein)

NP_003515

Location (UCSC)Chr 6: 26.25 – 26.25 MbChr 13: 22.02 – 22.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histone H2B type 1-H is a protein that in humans is encoded by the HIST1H2BH gene.[5][6][7]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000275713 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000069303 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
  6. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  7. 1 2 "Entrez Gene: HIST1H2BH histone cluster 1, H2bh".

Further reading


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