Plexxikon
TypeSubsidiary
IndustryBiotechnology
Founded2001 (2001)
FounderJoseph Schlessinger
Defunct2011 (2011)
FateAcquired by the Daiichi Sankyo
HeadquartersSouth San Francisco, California, United States.
Websitewww.plexxikon.com Edit this on Wikidata

Plexxikon is an American drug discovery company based in South San Francisco, California. It was co-founded in 2001 by Joseph Schlessinger of Yale University, and Sung-Hou Kim of the University of California, Berkeley.

It uses a proprietary structural biology-based platform called Scaffold-Based Drug Discovery to build a pipeline of products in multiple therapeutic areas. This discovery process integrates multiple technologies, including structural screening as one key component, that it hopes will give a significant competitive advantage over other approaches.[1]

In April 2011, Plexxikon was acquired by the Japanese pharmaceutical company Daiichi Sankyo for $805 million and an additional $130 million in potential milestone payments.[2][3][4]

Daiichi Sankyo announced the shutdown of Plexxikon in 2022.[5]

Drug pipeline

  • Plexxikon is collaborating with Wyeth Pharmaceuticals on several products for use in type II diabetes and other metabolic disorders.[6] The most advanced of these agents is indeglitazar (PLX204), which is currently in Phase II clinical trials for type 2 diabetes.[7]
  • PLX7486 is a CSF1R antagonist and pan-TRK inhibitor in clinical trials for advanced solid tumors.[8][9]

References

  1. ↑ "AI Drug Discovery: Key Trends and Developments in Pharmaceutical Industry". www.biopharmatrend.com. Retrieved 2023-09-11.
  2. ↑ "Daiichi Sankyo to Acquire Plexxikon". Plexxikon. 2011-02-28. Archived from the original on 2011-03-06.
  3. ↑ "Plexxikon acquired by Daiichi Sankyo". Haberman Associates. 2011-03-03. Retrieved 2020-08-06.
  4. ↑ "Daiichi Sankyo, Inc. Completes Plexxikon Inc. Acquisition". BioSpace. Retrieved 2020-08-06.
  5. ↑ Wells, Madeline (2022-01-12). "South SF company bought for $800 million is being shut down". SFGATE. Archived from the original on 2022-01-12.
  6. ↑ "Wyeth, Plexxikon tie up to develop novel diabetes & metabolic disorders treatment". 28 October 2004. Archived from the original on 24 October 2007.
  7. ↑ "Study Evaluating PPM-204 In Subjects With Type 2 Diabetes - Full Text View - ClinicalTrials.gov". Clinical Trials. Retrieved 2020-10-09.
  8. ↑ "Fms/Trk tyrosine kinase inhibitor PLX7486". NCI Drug Dictionary. National Cancer Institute.
  9. ↑ "Phase 1 Study of PLX7486 as Single Agent in Patients With Advanced Solid Tumors". ClinicalTrials.gov. 2018-08-02. Archived from the original on 2021-11-17.
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